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依铂(SKI-2053R)

依铂(SKI-2053R)用途

七铂(SKI 2053R)是一种铂衍生物,对多种癌细胞系具有抗癌活性,包括对顺铂耐药的肿瘤细胞系。SKI-2053R在胃腺癌的研究中非常活跃,具有良好的毒性特征[1]。

依铂(SKI-2053R)名称

[ CAS 号 ]:
146665-77-2

[ 中文名 ]:
依铂

[ 英文名 ]:
sunpla

[中文别名 ]:

[英文别名 ]:

(SP-4-2)-[(4R,5R)-2-Isopropyl-1,3-dioxolane-4,5
EPTAPLATIN,SUNPLA
SKI 2053R
sunpla
EPOXYPROGESTERONE
Heptaplatin

依铂(SKI-2053R)生物活性

[ 描述 ]:

七铂(SKI 2053R)是一种铂衍生物,对多种癌细胞系具有抗癌活性,包括对顺铂耐药的肿瘤细胞系。SKI-2053R在胃腺癌的研究中非常活跃,具有良好的毒性特征[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kim NK, et al. Phase II clinical trial of SKI-2053R, a new platinum analog, in the treatment of patients with advanced gastric adenocarcinoma. Cancer. 1999;86(7):1109-1115.

依铂(SKI-2053R)物理化学性质

[ 沸点 ]:
261.5ºC at 760 mmHg

[ 熔点 ]:
43-49ºC

[ 分子式 ]:
C₁₁H₂₀N₂O₆Pt

[ 分子量 ]:
471.36

[ 闪点 ]:
114ºC

[ 精确质量 ]:
471.096924

[ PSA ]:
123.10000

[ LogP ]:
0.45950

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0115mmHg at 25°C

[ 储存条件 ]:
2-8°C，避光，惰性气体保存

依铂(SKI-2053R)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2505900

CHEMICAL NAME :: Platinum, (2-(1-methylethyl)-1,3-dioxolane-4,5-dimethanamine-N, N')(propanedioato(2-) -O,O')-, (SP-4-2-(4R-(2-alpha,4-alpha,5-beta)))-

CAS REGISTRY NUMBER :: 146665-77-2

LAST UPDATED :: 199509

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H20-N2-O6-Pt

MOLECULAR WEIGHT :: 471.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1590 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,205,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 235 mg/kg/13W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,217,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 15 mg/kg/90D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Related to Chronic Data - death

REFERENCE :: KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1- 1985- Volume(issue)/page/year: 8,235,1992

依铂(SKI-2053R)安全信息

[ 危害码 (欧洲) ]:
Xn