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辛硫磷

辛硫磷用途

Phoxim 是一种有机磷农药,广泛用于农业。

辛硫磷名称

[ CAS 号 ]:
14816-18-3

[ 中文名 ]:
辛硫磷

[ 英文名 ]:
Phoxim

[中文别名 ]:

[英文别名 ]:

Caswell No. 902L
MFCD05863734
Volaton
Valexone
Valexon
Foxima [INN-Spanish]
Phoxim [INN:BAN]
Baythion
PHOXIM
EINECS 238-887-3

辛硫磷生物活性

[ 描述 ]:

Phoxim 是一种有机磷农药,广泛用于农业。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Sun Y, et, al. Vitamin E alleviates phoxim-induced toxic effects on intestinal oxidative stress, barrier function, and morphological changes in rats. Environ Sci Pollut Res Int. 2018 Sep; 25(26):26682-26692.

[2]. Li F, et, al. Effects of phoxim exposure on gut microbial composition in the silkworm, Bombyx mori. Ecotoxicol Environ Saf. 2020 Feb;189:110011.

辛硫磷物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
362.5±25.0 °C at 760 mmHg

[ 熔点 ]:
6.1ºC

[ 分子式 ]:
C₁₂H₁₅N₂O₃PS

[ 分子量 ]:
298.298

[ 闪点 ]:
173.0±23.2 °C

[ 精确质量 ]:
298.054108

[ PSA ]:
105.74000

[ LogP ]:
4.39

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.550

[ 储存条件 ]:
通风低温干燥

辛硫磷MSDS

详细MSDS(安全技术说明书)

辛硫磷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MD4740000

CHEMICAL NAME :: Glyoxylonitrile, phenyl-, oxime, O,O-diethyl phosphorothioate

CAS REGISTRY NUMBER :: 14816-18-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C12-H15-N2-O3-P-S

MOLECULAR WEIGHT :: 298.32

WISWESSER LINE NOTATION :: NCYR&UNOPS&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 7,299,1986

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3200 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A328,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,181,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 52OLAC "Veterinarnaya Entomologiya i Akarologiya," Veterinary Entomology and Acarology, Nepoklonov, A.A., ed., Moscow, Izdatel'stovo Kolos, 1983 Volume(issue)/page/year: -,230,1983

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 39,251,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BWHOA6 Bulletin of the World Health Organization. (WHO, Pub. Center USA, 49 Sheridan Ave., Albany, NY 12210) Volume(issue)/page/year: 44,31,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,181,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,181,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year: -,-,1971/1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,181,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 23700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- Volume(issue)/page/year: (680),157,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C39,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 23700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- Volume(issue)/page/year: (680),157,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 5620 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911- Volume(issue)/page/year: (680),157,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5642 mg/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(7),62,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 930 mg/kg/30D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 44(7),78,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 49 mg/kg

SEX/DURATION :: male 74 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 45(7),77,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1380 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

REFERENCE :: DDTWDG DTW, Deutsche Tieraerztliche Wochenschrift. (Verlag M. & H. Schaper, Postfach 1642, D-31061 Alfeld (Leine), Germany) V.78- 1971- Volume(issue)/page/year: 102,301,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2760 mg/kg

SEX/DURATION :: male 60 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: DDTWDG DTW, Deutsche Tieraerztliche Wochenschrift. (Verlag M. & H. Schaper, Postfach 1642, D-31061 Alfeld (Leine), Germany) V.78- 1971- Volume(issue)/page/year: 102,301,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2576 mg/kg

SEX/DURATION :: male 8 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: DDTWDG DTW, Deutsche Tieraerztliche Wochenschrift. (Verlag M. & H. Schaper, Postfach 1642, D-31061 Alfeld (Leine), Germany) V.78- 1971- Volume(issue)/page/year: 102,301,1995

辛硫磷安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H317-H330-H361f-H410

[ 警示性声明 ]:
P201-P260-P273-P280-P304 + P340 + P310-P403 + P233

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R50/53

[ 安全声明 (欧洲) ]:
S36-S60-S61

[ 危险品运输编码 ]:
UN 2810

[ RTECS号 ]:
MD4740000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2926909050

辛硫磷制备

用工业乙醇与亚硝酸钠、浓盐酸反应制得亚硝酸乙酯，再与苯乙腈反应制成2-氰基苯甲肟钠，然后与三氯硫磷和乙醇反应制得的乙基氯化物合成辛硫磷原油。将乙醇和亚硝酸钠混合，于20-40℃滴加盐酸制得亚硝酸乙酯。将其通过文氏管进入肟化釜，与釜内的苯乙腈、氢氧化钠的乙醇溶液反应，生成2-氰基苯甲肟钠。将其配制成25%水溶液，于室温下滴入乙基氯化物中。滴加后再加入三乙胺搅拌30min，升温至40-50℃继续反应1.5h。经水洗、分离、干燥而得辛硫磷原油。原料消耗定额：亚硝酸钠（95%）400kg/t、乙醇（95%）200kg/t、苯乙腈（96%）500kg/t、液碱（30%）680kg/t、盐酸（30%）680kg/t、氯化物（90%）750kg/t。

辛硫磷合成反应在丙酮等溶剂中进行较馔，在水溶液中稍慢，工业生产中2-肟基苯乙腈钠过量10%，反应温度40℃左右。天津农药厂曾研究了以水为溶剂催化合成法，所用催化剂为三乙胺，操作过程：将0.55mol含量25%的2-肟基苯乙腈钠水溶液373g，于室温下30min内滴加0.5mol含量为90%的O，O-二乙基硫代磷酰氯105g，滴毕，再加入少许催化剂三乙胺，搅拌30min，升温至45～50℃，反应1.5h，经水洗、分液、干燥得156～161g产品，含量87%～92%，收率94%～96%。

中间体2-肟基苯乙腈钠由苯乙腈与亚硝酸乙酯作用制得。催化剂为醇钠醇+NaOH、碱液等碱性物质。若以液碱为催化剂，反应温度35～40℃。

用工业乙醇与亚硝酸钠、浓盐酸反应制得亚硝酸乙酯，再与苯乙腈反应制成2-氰基苯甲肟钠，然后与三氯硫磷和乙醇反应制得的乙基氯化物合成辛硫磷原油。

辛硫磷海关

[ 海关编码 ]: 2926909050

[ 中文概述 ]:
2926909050 辛硫磷退税率:9.0% 监管条件:S(进出口农药登记证明)

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2926909050 (e)-o,o-diethyl ((cyano(phenyl)methylene)amino)oxyphosphonothioate

辛硫磷文献

Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen).

Arch. Insect Biochem. Physiol. 71(1) , 3-15, (2009)

The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists [triphenyl phosphate (TPP), piperonyl butoxide (PBO), and...

Cerium chloride improves protein and carbohydrate metabolism of fifth-instar larvae of Bombyx mori under phoxim toxicity.

Biol. Trace Elem. Res. 150(1-3) , 214-20, (2012)

The organophosphorus pesticide poisoning of the silkworm Bombyx mori is one of the major events causing serious damage to sericulture. Added low-dose rare earths are demonstrated to increase resistanc...

Investigation of photodegradation and hydrolysis of selected substituted urea and organophosphate pesticides in water.

Environ. Sci. Pollut. Res. Int. 18(6) , 949-57, (2011)

Photodegradation and hydrolysis of two substituted urea herbicides, monolinuron [3-(4-chlorophenyl)-1-methoxy-1-methylurea] and linuron [3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea], and one organop...

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辛硫磷