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CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-GLY-LYS-ARG (DISULFIDE BRIDGE: CYS1-CYS6)

用途

在非洲爪蟾的神经垂体中发现了1′Hydrin。Hydrin 1′在体外非洲爪蟾肾上腺中具有相当大的类固醇释放活性[1]。

名称

[ CAS 号 ]:
148440-73-7

[ 中文名 ]:
CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-GLY-LYS-ARG (DISULFIDE BRIDGE: CYS1-CYS6)

[ 英文名 ]:
Hydrin 1'

[英文别名 ]:

H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-GLY-LYS-OH
[Arg8]-Vasotocin-Gly-Lys
(ARG8,GLY10,LYS11)-VASOTOCIN
[ARG8]-VASOTOCIN-GLY-LYS
CYS-TYR-ILE-GLN-ASN-CYS-PRO-ARG-GLY-GLY-LYS

生物活性

[ 描述 ]:

在非洲爪蟾的神经垂体中发现了1′Hydrin。Hydrin 1′在体外非洲爪蟾肾上腺中具有相当大的类固醇释放活性[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Okada R, et al. Arginine vasotocin is the major adrenocorticotropic hormone-releasing factor in the bullfrog Rana catesbeiana. Gen Comp Endocrinol. 2016 Oct 1;237:121-130.

物理化学性质

[ 分子式 ]:
C₅₁H₈₁N₁₇O₁₅S₂

[ 分子量 ]:
1236.42

[ 精确质量 ]:
1235.55000

[ PSA ]:
590.46000

[ LogP ]:
1.07550

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

文献

Hydrins, hydroosmotic neurohypophysial peptides: osmoregulatory adaptation in amphibians through vasotocin precursor processing.

Proc. Natl. Acad. Sci. U. S. A. 86 , 5272-5275, (1989)

From neurointermediate pituitary glands of Xenopus laevis and Rana esculenta, previously unreported peptides termed hydrins, active on water permeability of frog urinary bladder and frog skin (Brunn o...

Correlation between aquaporin and water permeability in response to vasotocin, hydrin and {beta}-adrenergic effectors in the ventral pelvic skin of the tree frog Hyla japonica.

J. Exp. Biol. 213 , 288-294, (2010)

The ventral pelvic skin of the tree frog Hyla japonica expresses two kinds of arginine vasotocin (AVT)-stimulated aquaporins (AQP-h2 and AQP-h3), which affect the capacity of the frog's skin to absorb...

Molecular cloning of an anuran V(2) type [Arg(8)] vasotocin receptor and mesotocin receptor: functional characterization and tissue expression in the Japanese tree frog (Hyla japonica).

Gen. Comp. Endocrinol. 132 , 485-498, (2003)

In most amphibians, [Arg(8)] vasotocin (VT) has an antidiuretic effect that is coupled to the activation of adenylate cyclase. In contrast, mesotocin (MT) has a diuretic effect and acts via the inosit...

更多文献