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MNS

MNS用途

MNS是一个强的,选择性的Src 和Syk酪氨酸激酶。

MNS名称

[ CAS 号 ]:
1485-00-3

[ 中文名 ]:
3,4-亚甲二氧-beta-硝基苯乙烯

[ 英文名 ]:
MDBN

[中文别名 ]:

[英文别名 ]:

1,3-Benzodioxole, 5- (2-nitroethenyl)-
3,4-Methylenedioxy-β-nitrostyrene
5-[(E)-2-Nitrovinyl]-1,3-benzodioxole
1,3-Benzodioxole, 5-[(E)-2-nitroethenyl]-
T56 BO DO CHJ G1U1NW
MFCD00014575
5-(2-Nitrovinyl)benzo[d][1,3]dioxole
MNS

MNS生物活性

[ 描述 ]:

MNS是一个强的,选择性的Src 和Syk酪氨酸激酶。

[ 相关类别 ]:

信号通路 >> 蛋白酪氨酸激酶 >> SRC

信号通路 >> 蛋白酪氨酸激酶 >> SYK

研究领域 >> 癌症

[参考文献]

[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9.

[2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.

[相关活性小分子]

MNS物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
334.9±11.0 °C at 760 mmHg

[ 熔点 ]:
159-163 °C

[ 分子式 ]:
C₉H₇NO₄

[ 分子量 ]:
193.156

[ 闪点 ]:
168.8±21.3 °C

[ 精确质量 ]:
193.037506

[ PSA ]:
64.28000

[ LogP ]:
2.27

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.640

[ 储存条件 ]:
Store at +4°C

MNSMSDS

详细MSDS(安全技术说明书)

MNS毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WL5270000

CHEMICAL NAME :: Styrene, 3,4-methylenedioxy-beta-nitro-

CAS REGISTRY NUMBER :: 1485-00-3

BEILSTEIN REFERENCE NO. :: 0192350

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O4

MOLECULAR WEIGHT :: 193.17

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1U1NW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,375,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00689

MNS安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S36/37/39-S26-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ RTECS号 ]:
WL5270000

[ 海关编码 ]:
2932999099

MNS合成路线

详细合成路线

MNS上下游产品

MNS上游产品

MNS下游产品

MNS海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

MNS