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氯丁卡因

氯丁卡因用途

克利布卡因是一种哌啶衍生物,具有局部麻醉特性。克利布卡因可用作局部麻醉剂[1]。

氯丁卡因名称

[ CAS 号 ]:
15302-10-0

[ 中文名 ]:
氯丁卡因

[ 英文名 ]:
Clibucaine

[英文别名 ]:

Clibucaina
3-Piperidino-buttersaeure-(2,4-dichlor-anilid)
Clibucaine
Clibucaina [INN-Spanish]
3-piperidino-butyric acid-(2,4-dichloro-anilide)
Clibucainum [INN-Latin]

氯丁卡因生物活性

[ 描述 ]:

克利布卡因是一种哌啶衍生物,具有局部麻醉特性。克利布卡因可用作局部麻醉剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Dennie Van Den Heuvel, et al. Gastro-retentive oral dosage unit containing a local anaesthetic. Patent, WO2023094100A1.

氯丁卡因物理化学性质

[ 密度 ]:
1.255g/cm3

[ 沸点 ]:
466.8ºC at 760mmHg

[ 分子式 ]:
C₁₅H₂₀Cl₂N₂O

[ 分子量 ]:
315.24

[ 闪点 ]:
236.1ºC

[ 精确质量 ]:
314.09500

[ PSA ]:
35.83000

[ LogP ]:
4.78380

[ 蒸汽压 ]:
6.86E-09mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
室温

氯丁卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN3712310

CHEMICAL NAME :: 1-Piperidinepropionanilide, 2',4'-dichloro-beta-methyl-

CAS REGISTRY NUMBER :: 15302-10-0

BEILSTEIN REFERENCE NO. :: 0249881

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H20-Cl2-N2-O

MOLECULAR WEIGHT :: 315.27

WISWESSER LINE NOTATION :: T6NTJ AY1&1VMR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 38,1085,1955

氯丁卡因安全信息

[ 海关编码 ]:
2933399090

氯丁卡因合成路线

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氯丁卡因海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%