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迪-8-ANEPPS

迪-8-ANEPPS用途

Di-8-ANEPPS 是萘基苯乙烯基电压敏感染料，它们的荧光激发和发射光谱会因电压的变化而变化。

迪-8-ANEPPS名称

[ CAS 号 ]:
157134-53-7

[ 中文名 ]:
迪-8-ANEPPS

[ 英文名 ]:
Di-8-ANEPPS

[英文别名 ]:

Di-8-ANEPPS

迪-8-ANEPPS生物活性

[ 描述 ]:

Di-8-ANEPPS 是萘基苯乙烯基电压敏感染料,它们的荧光激发和发射光谱会因电压的变化而变化。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[体外研究]

用Di-8-ANEPPS染色的小鼠细胞施加电压钳制脉冲并浸入含Na +的溶液中。 Di-8-ANEPPS信号在很大程度上反映了t系统电压,在应用去极化脉冲时具有不对称的正分量。这被解释为反映了从电压钳位的质膜逃逸的传播动作电位。其时间属性与“中心”信号的时间属性没有什么不同。值得注意的是,信号的峰值出现在去极化脉冲前沿后0.3 ms [1]。

[细胞实验]

为了实施该技术，通过短暂暴露于具有Di-8-ANEPPS的盐水染色从小鼠屈肌腱（FDB）肌肉中酶促分离的细胞，然后在溶液中洗涤[1]。

[参考文献]

[1]. Manno C, et al. Confocal imaging of transmembrane voltage by SEER of di-8-ANEPPS. J Gen Physiol. 2013 Mar;141(3):371-87.

[相关活性小分子]

迪-8-ANEPPS物理化学性质

[ 分子式 ]:
C₃₆H₅₂N₂O₃S

[ 分子量 ]:
592.87500

[ 精确质量 ]:
592.37000

[ PSA ]:
72.70000

[ LogP ]:
9.84120

[ 储存条件 ]:
2-8℃

迪-8-ANEPPSMSDS

详细MSDS(安全技术说明书)

迪-8-ANEPPS安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

迪-8-ANEPPS文献

Cardiomyogenesis of embryonic stem cells upon purinergic receptor activation by ADP and ATP.

Purinergic Signal. 11 , 491-506, (2015)

Purinergic signaling may be involved in embryonic development of the heart. In the present study, the effects of purinergic receptor stimulation on cardiomyogenesis of mouse embryonic stem (ES) cells ...

Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation.

Circ. Cardiovasc. Genet. 8 , 427-36, (2015)

Differentiation of pluripotent human embryonic stem cells (hESCs) to the cardiac lineage represents a potentially unlimited source of ventricular cardiomyocytes (VCMs), but hESC-VCMs are developmental...

Optical signals from neurons with internally applied voltage-sensitive dyes.

J. Neurosci. 15 , 1392, (1995)

We carried out experiments to monitor optically the generation and spread of action potentials and subthreshold potentials in the processes of individual neurons in ganglia of the snail, Helix aspersa...

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