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(±)-2-propyl-4-Pentenoic Acid

(±)-2-propyl-4-Pentenoic Acid用途

(±)-2-丙基-4-戊烯酸(4-en-VPA)是丙戊酸的主要有毒代谢物。(±)-2-丙基-4-戊烯酸具有神经毒性[1][2]。

(±)-2-propyl-4-Pentenoic Acid名称

[ CAS 号 ]:
1575-72-0

[ 中文名 ]:
2-丙基-4-五烯酸

[ 英文名 ]:
(±)-2-Propyl-4-pentenoic acid

[中文别名 ]:

2-丙基-4-戊酸

[英文别名 ]:

2-propyl-4-pentenoic acid

(±)-2-propyl-4-Pentenoic Acid生物活性

[ 描述 ]:

(±)-2-丙基-4-戊烯酸(4-en-VPA)是丙戊酸的主要有毒代谢物。(±)-2-丙基-4-戊烯酸具有神经毒性[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

(±)-2-丙基-4-戊烯酸(1 mM；26 h)诱导约50%的小鼠胚胎发育不良[2]。

[参考文献]

[1]. W Tang, et, al. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics. Drug Metab Dispos. 1997 Feb;25(2):219-27.

[2]. Gofflot F, et, al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol Teratol. Jul-Aug 1995;17(4):425-35.

(±)-2-propyl-4-Pentenoic Acid物理化学性质

[ 密度 ]:
0.943g/cm3

[ 沸点 ]:
228.8ºC at 760mmHg

[ 分子式 ]:
C₈H₁₄O₂

[ 分子量 ]:
142.19600

[ 闪点 ]:
126.2ºC

[ 精确质量 ]:
142.09900

[ PSA ]:
37.30000

[ LogP ]:
2.06340

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.0257mmHg at 25°C

[ 折射率 ]:
1.448

[ 储存条件 ]:
2-8°C

(±)-2-propyl-4-Pentenoic Acid毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SB3362000

CHEMICAL NAME :: 4-Pentenoic acid, 2-propyl-

CAS REGISTRY NUMBER :: 1575-72-0

BEILSTEIN REFERENCE NO. :: 1704069

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H14-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 24,427,1985

(±)-2-propyl-4-Pentenoic Acid安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 危险品运输编码 ]:
UN 2810 6.1 / PGIII

[ RTECS号 ]:
SB3362000

[ 海关编码 ]:
2916190090

(±)-2-propyl-4-Pentenoic Acid合成路线

详细合成路线

(±)-2-propyl-4-Pentenoic Acid海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%