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5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐用途

SIN-1(氯化物)是莫西多明的活性代谢产物。SIN-1(氯化物)具有强大的血管舒张作用和抑制血小板聚集[1]。在心肌缺血再灌注模型中,SIN-1(氯化物)可减少心肌坏死和再灌注诱导的内皮功能障碍[2]。

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐名称

[ CAS 号 ]:
16142-27-1

[ 中文名 ]:
5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐

[ 英文名 ]:
Linsidomine hydrochloride

[中文别名 ]:

林西多明盐酸盐

[英文别名 ]:

3-(4-morpholinyl)-5-sydnone imine hydrochloride
T6N DOTJ A- AT5KNOYJ DUM &&sydnone
SIN-I HYDROCHLORIDE
LINSIDOMINE HCL
3-(4-morpholinyl)-sydnonimine hydrochloride
MFCD00221615
3-(4-Morpholinyl)sydnone imine hydrochloride
LinsidoMine Chlorhydrate
3-morpholinosydnone imine hydrochloride
MolsidoMine IMpurity A

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

[参考文献]

[1]. Nishikawa M,et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90.

[2]. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐物理化学性质

[ 熔点 ]:
186 °C

[ 分子式 ]:
C₆H₁₁ClN₄O₂

[ 分子量 ]:
206.630

[ 精确质量 ]:
206.057053

[ PSA ]:
67.28000

[ 外观性状 ]:
白色针状或略淡黄色白色结晶粉末

[ 储存条件 ]:
-20°C

[ 水溶解性 ]:
soluble

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐MSDS

详细MSDS(安全技术说明书)

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WU7687800

CHEMICAL NAME :: Sydnone imine, 3-morpholino-, monohydrochloride

CAS REGISTRY NUMBER :: 16142-27-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H10-N4-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐上下游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐上游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐下游产品

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐制备

可用4-氨基吗啉先以氰化钾、甲醛氰甲基化，生成4-（氰甲基氨基）吗啉，然后以亚硝酸钠亚硝化得4-（氰甲基亚硝基氨基）吗啉，后者在盐酸甲醇中环合得到本品。

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐文献

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Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.

Exp. Neurol. 233(1) , 154-62, (2012)

The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high gluco...

Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.

Free Radic. Res. 46(10) , 1190-200, (2012)

To study oxidative stress in biological systems, chemical compounds capable of producing free radicals have been widely used. Here, we compared two free-radical generators, 3-morpholinosydnonimine (SI...

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