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解毒喹

解毒喹用途

MQAE 是一种荧光氯离子指示剂，它比 ³⁶Cl 同位素示踪法和微电极法更灵敏，更有选择性。

解毒喹名称

[ CAS 号 ]:
162558-52-3

[ 中文名 ]:
解毒喹

[ 英文名 ]:
MQAE

[中文别名 ]:

MQAE(氯离子荧光探针)

[英文别名 ]:

MQAE

解毒喹生物活性

[ 描述 ]:

MQAE 是一种荧光氯离子指示剂,它比 36Cl 同位素示踪法和微电极法更灵敏,更有选择性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[体外研究]

浴用于急性脑切片,MQAE提供高质量的神经细胞标记及其过程[1]。 MQAE荧光是足以测量单个细胞中cAMP依赖性氯转运的可比方法[2]。 MQAE可用于测量大鼠主动脉平滑肌细胞(VSMC)原代培养物中的细胞内氯离子浓度[3]。

[参考文献]

[1]. Kovalchuk Y, et al. Two-photon chloride imaging using MQAE in vitro and in vivo. Cold Spring Harb Protoc. 2012 Jul 1;2012(7):778-85.

[2]. Andersson C, et al. Determination of chloride efflux by X-ray microanalysis versus MQAE-fluorescence. Microsc Res Tech. 2002 Dec 15;59(6):531-5.

[3]. Koncz C, et al. Use of MQAE for measurement of intracellular [Cl-] in cultured aortic smooth muscle cells. Am J Physiol. 1994 Dec;267(6 Pt 2):H2114-23.

[相关活性小分子]

解毒喹物理化学性质

[ 熔点 ]:
177-179ºC(lit.)

[ 分子式 ]:
C₁₄H₁₆BrNO₃

[ 分子量 ]:
326.18600

[ 精确质量 ]:
325.03100

[ PSA ]:
39.41000

[ 储存条件 ]:
-20℃

解毒喹MSDS

详细MSDS(安全技术说明书)

解毒喹安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933499090

解毒喹海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

解毒喹文献

Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications.

Anal. Biochem. 178 , 355, (1989)

A class of N-substituted quinoline compounds has been introduced recently for the fluorescence measurement of Cl concentration in biological preparations. The most Cl-sensitive compound was 6-methoxy-...

Hypoxia inhibits colonic ion transport via activation of AMP kinase.

Ann. Surg. 254 , 957-963, (2011)

Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mu...

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders.

Hepatology 50 , 861-870, (2009)

TGR5 (Gpbar-1) is a plasma membrane-bound, G protein-coupled receptor for bile acids. TGR5 messenger RNA (mRNA) has been detected in many tissues, including rat cholangiocytes and mouse gallbladder. A...

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解毒喹