地黄苷元
地黄苷元用途
地黄苷元名称
[ CAS 号 ]:
1672-46-4
[ 中文名 ]:
地黄苷元
[ 英文名 ]:
Digoxigenin
[中文别名 ]:
[英文别名 ]:
- Lanadigenin
- digitoxigenin
- MFCD00871861
- Lanadigigenin
- Digoxigenine
- Digoxigenin
- EINECS 216-806-2
地黄苷元生物活性
[ 描述 ]:
[ 相关类别 ]:
[相关活性小分子]
地黄苷元物理化学性质
[ 密度 ]:
1.297 g/cm3
[ 沸点 ]:
589.4ºC at 760 mmHg
[ 熔点 ]:
222 °C(lit.)
[ 分子式 ]:
C23H34O5
[ 分子量 ]:
390.51300
[ 闪点 ]:
203ºC
[ 精确质量 ]:
390.24100
[ PSA ]:
86.99000
[ LogP ]:
2.57510
[ 外观性状 ]:
白色固体
[ 蒸汽压 ]:
2.4E-16mmHg at 25°C
[ 折射率 ]:
1.609
[ 储存条件 ]:
2-8℃
地黄苷元MSDS
地黄苷元毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- FH5390000
- CHEMICAL NAME :
- 5-beta-Card-20(22)-enolide, 3-beta,12-beta,14-trihydroxy-
- CAS REGISTRY NUMBER :
- 1672-46-4
- BEILSTEIN REFERENCE NO. :
- 0096479
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C23-H34-O5
- MOLECULAR WEIGHT :
- 390.57
- WISWESSER LINE NOTATION :
- L E5 B666TJ A1 DQ E1 F- DT5OV CUTJ IQ OQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 244 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
- REFERENCE :
- JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year: 27,189,1938
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 285 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,55,1963
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 3545 ug/kg
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Behavioral - convulsions or effect on seizure threshold Cardiac - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 153,436,1965
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 1620 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 8,18,1960 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963
地黄苷元安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H300-H310-H330
[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310
[ 危害码 (欧洲) ]:
T+: Very toxic;
[ 风险声明 (欧洲) ]:
R26/27/28
[ 安全声明 (欧洲) ]:
S36/37/39-S45
[ 危险品运输编码 ]:
UN 2811 6.1/PG 1
[ WGK德国 ]:
3
[ RTECS号 ]:
FH5390000
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1(a)
地黄苷元上下游产品
地黄苷元上游产品
地黄苷元下游产品
地黄苷元文献
Biol. Open 4(2) , 146-54, (2015)
The formation of functional neuronal circuits relies on accurate migration and proper axonal outgrowth of neuronal precursors. On the route to their targets migrating cells and growing axons depend on...
Long-distance retinoid signaling in the zebra finch brain.PLoS ONE 9(11) , e111722, (2014)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, bu...
Local synthesis of interferon-alpha in lupus nephritis is associated with type I interferons signature and LMP7 induction in renal tubular epithelial cells.Arthritis. Res. Ther. 17 , 72, (2015)
Type I interferons are pivotal in the activation of autoimmune response in systemic lupus erythematous. However, the pathogenic role of interferon-alpha in patients affected by lupus nephritis remains...
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:地谷新配基
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥379.9/10mg
¥1899.9/100mg
¥749.9/25mg
¥1199.9/50mg
联系人:阿拉丁
产品详情:地高辛配基
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥594.0/10mg
¥1782.0/50mg
联系人:夏言
产品详情:[Perfemiker]Digoxigenin,≥99%
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相关化合物
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