1H-Pyrrole-2,5-dione,3-b-D-ribofuranosyl-

用途

Showdomycin 是一种抗生素,可由 IM-2 诱导 Streptomyces 产生。

名称

[ CAS 号 ]:
16755-07-0

[ 英文名 ]:
1H-Pyrrole-2,5-dione,3-b-D-ribofuranosyl-

[英文别名 ]:

生物活性

[ 描述 ]:

Showdomycin 是一种抗生素,可由 IM-2 诱导 Streptomyces 产生。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Hashimoto K, et al. IM-2, a butyrolactone autoregulator, induces production of several nucleoside antibiotics in Streptomyces sp. FRI-5[J]. Journal of fermentation and bioengineering, 1992, 73(6): 449-455.

物理化学性质

[ 密度 ]:
1.697g/cm3

[ 沸点 ]:
562.4ºC at 760mmHg

[ 分子式 ]:
C9H11NO6

[ 分子量 ]:
229.18700

[ 闪点 ]:
293.9ºC

[ 精确质量 ]:
229.05900

[ PSA ]:
116.09000

[ 蒸汽压 ]:
5.47E-15mmHg at 25°C

[ 折射率 ]:
1.648

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ON6200000
CHEMICAL NAME :
Maleimide, 2-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
16755-07-0
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H11-N-O6
MOLECULAR WEIGHT :
229.21
WISWESSER LINE NOTATION :
T5VMVJ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 17,148,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 17,148,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1443,1978

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相关化合物

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