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2,3-二羟基吡啶

2,3-二羟基吡啶用途

【用途一】
用作医药中间体

2,3-二羟基吡啶名称

[ CAS 号 ]:
16867-04-2

[ 中文名 ]:
2,3-二羟基吡啶

[ 英文名 ]:
hydroxypyridone

[中文别名 ]:

[英文别名 ]:

3-Dihydroxypyridine
2,3-hydroxypyridine
2,3-DIHYDROXYPYRIMIDINE
3-Hydroxypyridin-2(1H)-one
hydroxypyridinone
2(1H)-pyridinone, 3-hydroxy-
2,3-Dihydroxypyridine
3-Hydroxy-2(1H)-pyridinon
Pyridin-2,3-diol
2,3-dihydroxy pyridine

2,3-二羟基吡啶物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
441.4±25.0 °C at 760 mmHg

[ 熔点 ]:
245 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₅NO₂

[ 分子量 ]:
111.099

[ 闪点 ]:
220.8±23.2 °C

[ 精确质量 ]:
111.032028

[ PSA ]:
53.35000

[ LogP ]:
-0.60

[ 外观性状 ]:
棕色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
室温，惰性气体

2,3-二羟基吡啶MSDS

2,3-二羟基吡啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV1146700

CHEMICAL NAME :: 2(1H)-Pyridone, 3-hydroxy-

CAS REGISTRY NUMBER :: 16867-04-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H5-N-O2

MOLECULAR WEIGHT :: 111.11

WISWESSER LINE NOTATION :: T6NJ BQ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 879 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,815,1985

2,3-二羟基吡啶安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UV1146700

[ 海关编码 ]:
29333999

2,3-二羟基吡啶合成路线

2,3-二羟基吡啶上下游产品

2,3-二羟基吡啶上游产品

2,3-二羟基吡啶下游产品

2,3-二羟基吡啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,3-二羟基吡啶文献

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.

Bioorg. Med. Chem. Lett. 18 , 1567-72, (2008)

Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of p...

Connection of metallamacrocycles via dynamic covalent chemistry: a versatile method for the synthesis of molecular cages.

J. Am. Chem. Soc. 133(18) , 7106-15, (2011)

A modular approach for the synthesis of cage structures is described. Reactions of [(arene)RuCl(2)](2) [arene = p-cymene, 1,3,5-C(6)H(3)Me(3), 1,3,5-C(6)H(3)(i-Pr)(3)] with formyl-substituted 3-hydrox...

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