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4-氨基-1,8-萘二胺

4-氨基-1,8-萘二胺用途

4-氨基萘酰亚胺是一种有效的PARP抑制剂,可增强癌细胞γ辐射的细胞毒性[1]。

4-氨基-1,8-萘二胺名称

[ CAS 号 ]:
1742-95-6

[ 中文名 ]:
4-氨基-1,8-萘胺

[ 英文名 ]:
4-AMINO-1,8-NAPHTHALIMIDE

[中文别名 ]:

[英文别名 ]:

6-aminobenzo[de]isoquinoline-1,3-dione
EINECS 217-092-5
4-Amino-1,8-naphthalimide
6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione
MFCD00001892

4-氨基-1,8-萘二胺生物活性

[ 描述 ]:

4-氨基萘酰亚胺是一种有效的PARP抑制剂,可增强癌细胞γ辐射的细胞毒性[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 表观遗传学 >> PARP

信号通路 >> 细胞周期/DNA损伤 >> PARP

[参考文献]

[1]. Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly(ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75(1):91-100.

4-氨基-1,8-萘二胺物理化学性质

[ 密度 ]:
1.105 g/mL at 25ºC(lit.)

[ 沸点 ]:
544.1ºC at 760 mmHg

[ 熔点 ]:
360ºC

[ 分子式 ]:
C₁₂H₈N₂O₂

[ 分子量 ]:
212.20

[ 闪点 ]:
282.8ºC

[ 精确质量 ]:
212.05900

[ PSA ]:
75.95000

[ LogP ]:
1.64270

[ 外观性状 ]:
橙色固体

[ 蒸汽压 ]:
6.75E-12mmHg at 25°C

[ 折射率 ]:
1.764

[ 储存条件 ]:
-20°C，避光，干燥

4-氨基-1,8-萘二胺MSDS

4-氨基-1,8-萘二胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4081000

CHEMICAL NAME :: 1H-Benz(de)isoquinoline-1,3(2H)-dione, 6-amino-

CAS REGISTRY NUMBER :: 1742-95-6

BEILSTEIN REFERENCE NO. :: 0177185

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H8-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 42(1),111,1977

4-氨基-1,8-萘二胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
DE4081000

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4-氨基-1,8-萘二胺文献

A new polymerizable fluorescent PET chemosensor of fluoride (F-) based on naphthalimide-thiourea dye.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 90 , 85-92, (2012)

A novel N-allyl-4-amino-substituted 1,8-naphthalimide dye, containing thiourea functional group with intense yellow-green fluorescence was successfully synthesized. Copolymerization was done with styr...

Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.

DNA Repair (Amst.) 12(9) , 774-85, (2013)

Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key B...

[Effect of PARP-1 inhibitor 4-amino-1 ,8-naphthalimide on the on the sensitivity of adriamycin].

Wei Sheng Yan Jiu 41(2) , 173-9, (2012)

To explore the effect of inhibition of poly (ADP-ribose) polymerase-1 (PARP-1) on the sensitivity of cells to adriamycin (ADM).Mouse embryonic fibroblasts (MEFs) were divided into two groups according...

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