去乙酰毛花苷

去乙酰毛花苷用途

Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,用于治疗充血性心力衰竭和因折返机制引起的室上性心律失常,并在治疗慢性心房颤动时控制心室率。Deslanoside 抑制Na-K-ATPase膜泵,导致细胞内钠和钙浓度增加。

去乙酰毛花苷名称

[ CAS 号 ]:
17598-65-1

[ 中文名 ]:
去乙酰毛花苷

[ 英文名 ]:
Deslanoside

[中文别名 ]:

毛地黄苷C

[英文别名 ]:

Deacetyllanatoside C
Desacetyllanatoside C
Deslanatoside C
Deslanoside
Deacetyllanatoside C,Desacetyllanatoside C
Cedilanide
deacetyl-lanatoside
4-18-00-02455 (Beilstein Handbook Reference)
Desacetyldigilanide C
Descetyldigilanide C

去乙酰毛花苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

[体外研究]

去乙酰甲苷(Desacetyllanatoside C)是兰豆苷C的代谢产物[4]。地塞米松增加前臂血流量和心脏指数,降低心率,同时骨骼肌交感神经活动显著降低,作为中枢介导交感神经系统活动的指标[1]。

[参考文献]

[1]. Hauptman PJ, et al. Digitalis. Circulation. 1999 Mar 9;99(9):1265-70.

[2]. Wang L, et al. Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in China. Sci Rep. 2017 Oct 23;7(1):13819.

[3]. Deslanoside.

[4]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

[5]. Klys M, et al. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report. Forensic Sci Int. 1990 Apr;45(3):231-8.

去乙酰毛花苷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
220-235ºC

[ 分子式 ]:
C₄₇H₇₄O₁₉

[ 分子量 ]:
943.079

[ 精确质量 ]:
942.482422

[ PSA ]:
282.21000

[ LogP ]:
-1.40

[ 折射率 ]:
1.620

[ 储存条件 ]:
2-8°C

去乙酰毛花苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OE2100500

CHEMICAL NAME :: Lanatoside C, deacetyl-

CAS REGISTRY NUMBER :: 17598-65-1

BEILSTEIN REFERENCE NO. :: 0078187

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C47-H74-O19

MOLECULAR WEIGHT :: 943.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10360 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,489,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,489,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 230 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,190,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7349 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 103 (estimated) No. of Female Employees: 52 (estimated)

去乙酰毛花苷安全信息

[ 风险声明 (欧洲) ]:
R23/25

[ 安全声明 (欧洲) ]:
1-22-45

[ 危险品运输编码 ]:
UN 2811

去乙酰毛花苷合成路线

详细合成路线

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去乙酰毛花苷文献

Effects of acute administration of ethanol on experimental arrhythmia.

Chin. J. Physiol. 55(5) , 307-13, (2012)

Many studies have shown that the relationship between alcohol consumption and most cardiovascular diseases is U-shaped, with nondrinkers and heavier drinkers having higher risks than moderate drinkers...

Altered vagal and sympathetic control of heart rate in left ventricular dysfunction and heart failure.

Am. J. Physiol. 268(2 Pt 2) , R310-16, (1995)

We investigated alterations in autonomic control of heart rate in conscious dogs with left ventricular (LV) dysfunction in the presence and absence of heart failure (HF) due to rapid pacing. In dogs w...

Two-stage cultivation of Digitalis lanata cells: semicontinuous production of deacetyllanatoside C in 20-litre airlift bioreactors.

J. Biotechnol. 16(1-2) , 123-35, (1990)

A two-stage cultivation method was employed to develop a semicontinuous biotransformation process for the production of deacetyllanatoside C, a cardenolide of the important digoxin series. Digitoxin w...

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