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岩藻甾醇

岩藻甾醇用途

Fucosterol 是从 E. stolonifera 中分离出来的,具有抗脂肪形成,抗糖尿病和抗癌活性。 Fucosterol 通过调节 PPARα 和 C/EBPα 的表达来调节脂肪形成。

岩藻甾醇名称

[ CAS 号 ]:
17605-67-3

[ 中文名 ]:
岩皂甾醇

[ 英文名 ]:
Fucosterol

[中文别名 ]:

[英文别名 ]:

trans-24-Ethylidenecholesterol
D5-avenasterol
MFCD00037543
FUCOSTEROL
Fucosterin
trans-Stigmasta-5,24(28)-dien-3b-ol
24-ETHYLIDENCHOLEST-5-ENE-3B-OL

岩藻甾醇生物活性

[ 描述 ]:

Fucosterol 是从 E. stolonifera 中分离出来的,具有抗脂肪形成,抗糖尿病和抗癌活性。 Fucosterol 通过调节 PPARα 和 C/EBPα 的表达来调节脂肪形成。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 表观遗传学 >> PARP

信号通路 >> 细胞周期/DNA损伤 >> PARP

[ 靶点 ]

PPARα; C/EBPα[1]

[体外研究]

与完全分化的对照脂肪细胞相比,岩藻糖醇(0-50μM；7天)抑制PPARα和C/EBPα的表达[1]。岩藻糖醇对T47D和HT29细胞系具有细胞毒性,IC50值分别为27.94和70.41μg/ml,分别[3]。岩藻糖醇降低细胞HEK293,MCF-7和SiHa细胞增殖,IC50值分别为185.4,43.3和34.0μg/ml[4]。细胞活力测定[1]细胞系：3T3-L1脂肪细胞浓度：0μM；25μM；50μM孵育时间：7天结果：抑制PPARα和C/EBPα表达。

[体内研究]

岩藻糖醇(口服给药；30mg/kg)导致血清葡萄糖浓度显着降低,并表现出对镜片中山梨糖醇积累的抑制[2]。

[参考文献]

[1]. Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37(6):713-20.

[2]. Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27(11):1120-2.

[3]. Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8(29):60-4.

[4]. Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52(10):1244-8.

岩藻甾醇物理化学性质

[ 密度 ]:
0.98 g/cm3

[ 沸点 ]:
504.2ºC at 760 mmHg

[ 熔点 ]:
118-120ºC

[ 分子式 ]:
C₂₉H₄₈O

[ 分子量 ]:
412.69100

[ 闪点 ]:
220.3ºC

[ 精确质量 ]:
412.37100

[ PSA ]:
20.23000

[ LogP ]:
7.94490

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
2.8E-12mmHg at 25°C

[ 折射率 ]:
1.53

[ 储存条件 ]:
2-8°C

岩藻甾醇MSDS

详细MSDS(安全技术说明书)

岩藻甾醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

岩藻甾醇文献

Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera.

Chem. Biol. Interact. 206(1) , 55-62, (2013)

In the present study, we investigated the anti-diabetic potential of fucosterol by evaluating the ability of this compound to inhibit rat lens aldose reductase (RLAR), human recombinant aldose reducta...

The effect of traditional stir-frying process on hydrophilic and lipophilic antioxidant capacities of pine nut kernels.

Int. J. Food Sci. Nutr. 66 , 873-80, (2015)

The effect of traditional stir-frying process at different heating temperatures (50-150 °C) and time periods (5-20 min) on hydrophilic part (total and individual phenolics), lipophilic part (tocophero...

Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens.

J. Nat. Prod. 64(11) , 1463-4, (2001)

Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Vero cells was ...

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