2-甲基-4(1H)-喹唑啉酮

2-甲基-4(1H)-喹唑啉酮用途

2-Methylquinazolin-4-ol 是一种高效、竞争性的 poly(ADP-ribose) synthetase 抑制剂,其 Ki 值为 1.1 μM。2-Methylquinazolin-4-ol 是哺乳动物天冬氨酸氨基转移酶 (ATCase) 抑制剂,其 IC50 值为 0.20 mM。

2-甲基-4(1H)-喹唑啉酮名称

[ CAS 号 ]:
1769-24-0

[ 中文名 ]:
2-甲基-4(3H)-喹唑酮

[ 英文名 ]:
2-Methylquinazolin-4-ol

[中文别名 ]:

[英文别名 ]:

EINECS 217-189-2
MFCD00006887
2-methyl-4(3h)-quinazolinone

2-甲基-4(1H)-喹唑啉酮生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PARP

研究领域 >> 其他

信号通路 >> 细胞周期/DNA损伤 >> PARP

[体外研究]

2-甲基喹唑啉-4-醇以浓度依赖性方式抑制ATCase[1]。

[体内研究]

2-甲基喹唑啉-4-醇(0.2-1毫克；i、 g。；两天)在体内以剂量依赖的方式抑制ATCase[2]。动物模型：小鼠[2]剂量：0.2mg、0.4mg、0.6mg、0.8mg、1mg灌胃给药,连续2天。结果：对ATCase有抑制作用。

[参考文献]

[1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2.

[2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92.

2-甲基-4(1H)-喹唑啉酮物理化学性质

[ 密度 ]:
1.26 g/cm3

[ 沸点 ]:
305.4ºC at 760 mmHg

[ 熔点 ]:
231-233ºC(lit.)

[ 分子式 ]:
C₉H₈N₂O

[ 分子量 ]:
160.17300

[ 闪点 ]:
138.5ºC

[ 精确质量 ]:
160.06400

[ PSA ]:
45.75000

[ LogP ]:
1.23150

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
室温

2-甲基-4(1H)-喹唑啉酮MSDS

详细MSDS(安全技术说明书)

2-甲基-4(1H)-喹唑啉酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3677000

CHEMICAL NAME :: 4(3H)-Quinazolinone, 2-methyl-

CAS REGISTRY NUMBER :: 1769-24-0

LAST UPDATED :: 199609

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H8-N2-O

MOLECULAR WEIGHT :: 160.19

WISWESSER LINE NOTATION :: T66 BVM ENJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 859 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 592 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - tremor Behavioral - muscle weakness

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 7,626,1973

2-甲基-4(1H)-喹唑啉酮安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26;S37/S39

[ WGK德国 ]:
3

[ RTECS号 ]:
VA3677000

[ 海关编码 ]:
2933990090

2-甲基-4(1H)-喹唑啉酮合成路线

详细合成路线

2-甲基-4(1H)-喹唑啉酮上下游产品

2-甲基-4(1H)-喹唑啉酮上游产品

2-甲基-4(1H)-喹唑啉酮下游产品

2-甲基-4(1H)-喹唑啉酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%