纺锤菌素二盐酸

Netropsin (dihydrochloride) 是一种小分子(MGB) 小沟结合剂,抑制分离的拓扑异构酶的催化活性,并干扰拓扑异构酶 II 和 I 在细胞核中的可切割复合物的稳定性。Netropsin (dihydrochloride) 通过以非插入方式与 dsDNA 结合而具有潜在的抗生素和抗病毒特性,它通过干扰 HMGA1 DNA 与核心NOS2 启动子的结合来减弱 NOS2 的诱导作用,从而提高小鼠内毒素血症的存活率。DNA 溶液中 的 Netropsin (dihydrochloride) 由于其高结合亲和力和高结构稳定性而具有辐射诱导损伤的辐射保护能力,电离辐射产生的羟基自由基 (OH*) 不能对 netropsin-DNA 复合物进行放射性降解。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 分子式 ]:
C₁₈H₂₈Cl₂N₁₀O₃

[ 分子量 ]:
466.92500

[ 精确质量 ]:
466.19600

[ PSA ]:
208.93000

[ LogP ]:
2.42320

[ 储存条件 ]:
-20°C

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
DW2973000

Free energy calculations offer insights into the influence of receptor flexibility on ligand-receptor binding affinities.

J. Comput. Aided Mol. Des. 25(8) , 709-16, (2011)

Docking algorithms for computer-aided drug discovery and design often ignore or restrain the flexibility of the receptor, which may lead to a loss of accuracy of the relative free enthalpies of bindin...

Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.

PLoS ONE 6(5) , e17446, (2011)

Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesiz...

DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells.

Bioorg. Med. Chem. 19 , 5093-102, (2011)

A compound that can target cells expressing the estrogen receptor (ER), and produce predominantly 3-MeA adducts in those cells has been designed and synthesized. This compound produces mainly the 3-Me...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：纺锤菌素二盐酸

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1853.9/5mg ￥需询单/1g ￥需询单/1g ￥需询单/5g

联系人：阿拉丁

产品详情：纺锤菌素 二盐酸盐

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