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3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧

3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧用途

PTIO是NO的一种特殊清除剂。PTIO与•NO反应生成相应的亚氨基氮氧化物和•NO2[1]。

3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧名称

[ CAS 号 ]:
18390-00-6

[ 中文名 ]:
3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧

[ 英文名 ]:
PTIO

[中文别名 ]:

[英文别名 ]:

PTIO

3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧生物活性

[ 描述 ]:

PTIO是NO的一种特殊清除剂。PTIO与•NO反应生成相应的亚氨基氮氧化物和•NO2[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Xia JL , et al. Putrescine regulates nitric oxide accumulation in Ganoderma lucidum partly by influencing cellular glutamine levels under heat stress. Microbiol Res. 2020;239:126521.

[2]. Goldstein S, et al. Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*. J Biol Chem. 2003;278(51):50949-50955.

3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧物理化学性质

[ 密度 ]:
1.17g/cm3

[ 沸点 ]:
359.7ºC at 760mmHg

[ 分子式 ]:
C₁₃H₁₇N₂O₂

[ 分子量 ]:
233.286

[ 闪点 ]:
171.3ºC

[ 精确质量 ]:
233.128998

[ PSA ]:
31.99000

[ LogP ]:
2.05850

[ 外观性状 ]:
固体;Blue to Dark blue powder to crystal

[ 储存条件 ]:
0-10°C;避免光,加热

[ 水溶解性 ]:
可溶于：甲醇

3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧MSDS

详细MSDS(安全技术说明书)

3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

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3-氧代-2-苯基-4,4,5,5-四甲基咪唑啉-1-氧文献

Nitric oxide induces cancer stem cell-like phenotypes in human lung cancer cells.

Am. J. Physiol. Cell Physiol. 308(2) , C89-100, (2015)

Even though tremendous advances have been made in the treatment of cancers during the past decades, the success rate among patients with cancer is still dismal, largely because of problems associated ...

Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke.

J. Neurosci. 34(40) , 13535-48, (2014)

Stroke is a major public health concern. The lack of effective therapies heightens the need for new therapeutic targets. Mammalian brain has the ability to rewire itself to restore lost functionalitie...

Cardiac contractility in Antarctic teleost is modulated by nitrite through xanthine oxidase and cytochrome p-450 nitrite reductase.

Nitric Oxide 49 , 1-7, (2015)

In mammalian and non-mammalian vertebrates, nitrite anion, the largest pool of intravascular and tissue nitric oxide storage, represents a key player of many biological processes, including cardiac mo...

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