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毒草胺

毒草胺用途

Propachlor is a specific ALDH1A1 inhibitor. It is sometimes used as an herbicide.

毒草胺名称

[ CAS 号 ]:
1918-16-7

[ 中文名 ]:
毒草胺

[ 英文名 ]:
Propachlor

[中文别名 ]:

[英文别名 ]:

2-Chloro-N-isopropylacetanilide
Satecid
N-isopropyl-2-chloroacetanilide
2-Chloro-N-isopropyl-N-phenyl-acetamide
Niticid
N-isopropyl-N-phenyl-chloroacetamide
2-Chloro-N-isopropyl-N-phenylacetamide
Prolex
Propachlore
2-Chloro-N-(1-methylethyl)-N-phenylacetamide (9CI)

毒草胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
290.4±23.0 °C at 760 mmHg

[ 熔点 ]:
67-76°C

[ 分子式 ]:
C₁₁H₁₄ClNO

[ 分子量 ]:
211.688

[ 闪点 ]:
129.4±22.6 °C

[ 精确质量 ]:
211.076385

[ PSA ]:
20.31000

[ LogP ]:
2.28

[ 外观性状 ]:
淡黄褐色的结晶粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

毒草胺MSDS

详细MSDS(安全技术说明书)

毒草胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE1575000

CHEMICAL NAME :: Acetanilide, 2-chloro-N-isopropyl-

CAS REGISTRY NUMBER :: 1918-16-7

LAST UPDATED :: 199806

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C11-H14-Cl-N-O

MOLECULAR WEIGHT :: 211.71

WISWESSER LINE NOTATION :: G1VNR&Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1056 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 306 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 392 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 91 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 512 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3458 mg/kg/26W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1400 mg/kg/20D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Blood - pigmented or nucleated red blood cells Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 14(6),38,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

毒草胺安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H319-H410

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R36;R43;R50/53

[ 安全声明 (欧洲) ]:
S24-S37-S60-S61

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
AE1575000

[ 海关编码 ]:
2924299014

毒草胺上下游产品

毒草胺上游产品

毒草胺下游产品

毒草胺制备

苯胺与2-氯丙烷在130-140℃，约1MPa压力下反应4h，降温至95℃，泄压后缓慢滴加氯乙酰氯，于100℃反应3h，即制得毒草胺。原料消耗定额：苯胺530kg/t、丙烯410kg/t、盐酸520kg/t、氯乙酰氯740kg/t、氯化钙200kg/t。

毒草胺海关

[ 海关编码 ]: 2924299014

[ 中文概述 ]:
2924299014 毒草胺、丁烯草胺、二氯己酰草胺。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2924299014 2-chloro-n-isopropyl-n-phenylacetamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

毒草胺文献

Glutathione-dependent cytotoxicity of the chloroacetanilide herbicides alachlor, metolachlor, and propachlor in rat and human hepatoma-derived cultured cells.

Cell Biol. Toxicol. 15(5) , 325-32, (1999)

Alachlor, metolachlor, and propachlor are widely used chloroacetanilide herbicides. Their cytotoxicity in rat (Fa32) and human (Hep G2) hepatoma-derived cells was investigated, in connection with thei...

Kinetics and mechanism of propachlor reductive transformation through nucleophilic substitution by dithionite

Chemosphere 85(9) , 1438-43, (2011)

Highlights ► The reductive dechlorination of propachlor was efficiently achieved by dithionite. ► The transformation of propachlor initiated by dithionite follows second-order kinetics. ► Dechlorinati...

Characterization of glutathione conjugates of chloroacetanilide pesticides using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry.

Rapid Commun. Mass Spectrom. 21(24) , 4017-22, (2007)

Glutathione S-transferases (GSTs) isolated from maize were used to catalyze the conjugation of glutathione (GSH) with chloroacetanilide herbicides, producing stable conjugates that were structurally c...

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毒草胺