壳梭孢(菌)素

壳梭孢(菌)素用途

Fusicoccin (Fusicoccin A),一种真菌化脓毒素,14-3-3 蛋白相互作用的稳定剂。Fusicoccin 使 H+-ATPase/14-3-3 复合物在植物中稳定,保持酶的激活状态。Fusicoccin 还稳定 14-3-3 蛋白与含有 C-末端 14-3-3 识别基序的结合伙伴的相互作用,如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 诱导一些癌细胞调亡,并具有抗癌活性。

壳梭孢(菌)素名称

[ CAS 号 ]:
20108-30-9

[ 中文名 ]:
壳梭孢(菌)素

[ 英文名 ]:
Fusicoccin-A

[中文别名 ]:

壳梭孢菌素

[英文别名 ]:

MFCD00070322
FUSICOCCIN
Fucicoccin
fusicoccin A

壳梭孢(菌)素生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[体外研究]

熔丝球蛋白(fuscoccin A)稳定14-3-3和压力响应调节器GCN1之间的复合物,诱导GCN1翻转和突起生长(EC50=29mm)[3]。梭孢菌素A通过稳定与14-3-3蛋白的结合而激活质膜H+-ATPase,导致植株失水和枯萎。在体外,梭球菌素A可降低人GBM细胞系的增殖和迁移,包括对促凋亡刺激表现出不同程度抵抗的细胞系。在U373-MG细胞中,熔丝球蛋白A的IC50生长抑制浓度为92µM,在Hs683胶质瘤细胞中为83µM[4]。

[参考文献]

[1]. Camoni L, et al. The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?. IUBMB Life. 2013;65(6):513-517.

[2]. Doveston RG, et al. Small-molecule stabilization of the p53-14-3-3 protein-protein interaction. FEBS Lett. 2017;591(16):2449-2457.

[3]. Kaplan A, et al. Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration. Neuron. 2017;93(5):1082-1093.e5.

[4]. Bury M, et al. Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases. Transl Oncol. 2013;6(2):112-123.

壳梭孢(菌)素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
760.2±60.0 °C at 760 mmHg

[ 分子式 ]:
C₃₆H₅₆O₁₂

[ 分子量 ]:
680.823

[ 闪点 ]:
227.0±26.4 °C

[ 精确质量 ]:
680.377197

[ PSA ]:
170.44000

[ LogP ]:
3.28

[ 蒸汽压 ]:
0.0±5.8 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
-20°C，密闭，干燥

壳梭孢(菌)素MSDS

详细MSDS(安全技术说明书)

壳梭孢(菌)素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

壳梭孢(菌)素文献

Identification and characterisation of the phenolics of Ilex glabra L. Gray (Aquifoliaceae) leaves by liquid chromatography tandem mass spectrometry.

Plant Physiol. Biochem. 70 , 504-11, (2013)

The phenolics of the leaves of Ilex glabra L. Gray (Aquifoliaceae) were investigated qualitatively by LC-MS(n). Thirty-two phenolics were detected and characterised on the basis of their unique fragme...

Apoplastic alkalinization is instrumental for the inhibition of cell elongation in the Arabidopsis root by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid.

Plant Physiol. 155(4) , 2049-55, (2011)

In Arabidopsis (Arabidopsis thaliana; Columbia-0) roots, the so-called zone of cell elongation comprises two clearly different domains: the transition zone, a postmeristematic region (approximately 20...

Characterization of the plasma membrane H+-ATPase in the liverwort Marchantia polymorpha.

Plant Physiol. 159(2) , 826-34, (2012)

The plasma membrane H(+)-ATPase generates an electrochemical gradient of H(+) across the plasma membrane that provides the driving force for solute transport and regulates pH homeostasis and membrane ...

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