硫酸奎宁水合物

硫酸奎宁水合物用途

Quinine hemisulfate hydrate 是一种从金鸡纳树皮中提取的生物碱,具有抗疟疾的作用。Quinine hemisulfate hydrate 是一种钾离子通道 (potassium channel) 抑制剂,可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。

硫酸奎宁水合物名称

[ CAS 号 ]:
207671-44-1

[ 中文名 ]:
奎宁半硫酸盐一水合物

[ 英文名 ]:
Quinine hemisulfate hydrate

[中文别名 ]:

奎宁半硫酸盐一水合物

[英文别名 ]:

Quinine hemisulfate
Quinine sulfate

硫酸奎宁水合物生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 跨膜转运 >> 钾通道

[ 靶点 ]

IC50: Parasite[1], 169 μM (mSlo3)[2]

[参考文献]

[1]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144.

[2]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63.

硫酸奎宁水合物物理化学性质

[ 分子式 ]:
C₂₀H₂₄N₂O_2.1/₂H₂O₄S_.H₂O

[ 分子量 ]:
782.94300

[ 精确质量 ]:
782.35600

[ PSA ]:
192.62000

[ LogP ]:
6.52160

[ 储存条件 ]:
-20°C，干燥，密封

硫酸奎宁水合物安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

硫酸奎宁水合物文献

Interaction of quinine sulfate with anionic micelles of sodium dodecylsulfate: A time-resolved fluorescence spectroscopy at different pH.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 148 , 49-59, (2015)

Photophysical behavior and rotational relaxation dynamics of quinine sulfate (QS) in anionic surfactant, sodium dodecylsulfate (SDS) at different pH have been studied using steady state and time resol...

The uptake of trehalose glycolipids by macrophages is independent of Mincle.

ChemBioChem. 16(4) , 683-93, (2015)

Trehalose glycolipids play an important role in the pathogenesis of Mycobacterium tuberculosis and are used as adjuvants for vaccines; however, much still remains unanswered about the mechanisms throu...

In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives.

Antimicrob. Agents Chemother. 59 , 3271-80, (2015)

4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stabilit...

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