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5-溴烟酸

5-溴烟酸用途

5-溴烟酸是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

5-溴烟酸名称

[ CAS 号 ]:
20826-04-4

[ 中文名 ]:
5-溴烟酸

[ 英文名 ]:
5-Bromonicotinic acid

[中文别名 ]:

[英文别名 ]:

Nicotinic acid,5-bromo
5-Bromonicotinic acid
5-Bromo-3-pyridinecarboxylic Acid
3-Pyridinecarboxylic acid,5-bromo
3-bromo-5-pyridine-carboxylic acid
5-bromonictotinic acid
3-Bromo pyridine-5-carboxylic acid
5-bromonicotininc acid
3-Pyridinecarboxylic acid, 5-bromo-
5-Bromopyridine-3-carboxylic acid

5-溴烟酸生物活性

[ 描述 ]:

5-溴烟酸是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

5-溴烟酸物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
328.5±27.0 °C at 760 mmHg

[ 熔点 ]:
178-180 °C(lit.)

[ 分子式 ]:
C₆H₄BrNO₂

[ 分子量 ]:
202.01

[ 闪点 ]:
152.5±23.7 °C

[ 精确质量 ]:
200.942535

[ PSA ]:
50.19000

[ LogP ]:
1.22

[ 外观性状 ]:
淡黄色结晶

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.617

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

5-溴烟酸MSDS

5-溴烟酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT0868000

CHEMICAL NAME :: Nicotinic acid, 5-bromo-

CAS REGISTRY NUMBER :: 20826-04-4

BEILSTEIN REFERENCE NO. :: 0115854

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H4-Br-N-O2

MOLECULAR WEIGHT :: 202.02

WISWESSER LINE NOTATION :: T6NJ CE EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 462 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year: 10,35,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,29,1986

5-溴烟酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QT0868000

[ 海关编码 ]:
2933399090

5-溴烟酸合成路线

5-溴烟酸上下游产品

5-溴烟酸上游产品

5-溴烟酸下游产品

5-溴烟酸制备

5-溴烟酸海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-溴烟酸文献

Agonist lead identification for the high affinity niacin receptor GPR109a.

Bioorg. Med. Chem. Lett. 17 , 4914-9, (2007)

A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hyp...

Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine.

Bioconjug. Chem. 9(6) , 758-64, (1998)

Substituting a pyridine ring for a benzene ring in the acylation agent N-succinimidyl 3-iodobenzoate has resulted in a useful approach for the radiohalogenation of monoclonal antibodies, peptides, and...

Drug-protein conjugates: haptenation of 1-methyl-10 alpha-methoxydihydrolysergol and 5-bromonicotinic acid to albumin for the production of epitope-specific monoclonal antibodies against nicergoline.

J. Pharm. Sci. 84(9) , 1120-5, (1995)

Two types of monoclonal antibodies were used for the determination of nicergoline in biological matrices. The antibodies were prepared with the hydrolysis products 5-bromonicotinic acid and 1-methyl-1...

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