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7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

用途

8-氮杂鸟苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

[ CAS 号 ]:
2133-80-4

[ 英文名 ]:
7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one,5-amino-3,4-dihydro-3-b-D-ribofuranosyl-

[英文别名 ]:

8-Aza-guanosin
9-ss-D-ribofuranosyl-8-aza-guanin
Azaguanosine
8-aza-guanosine

生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

[ 密度 ]:
2.49g/cm3

[ 沸点 ]:
567.3ºC at 760 mmHg

[ 分子式 ]:
C₉H₁₂N₆O₅

[ 分子量 ]:
284.23

[ 闪点 ]:
296.9ºC

[ 精确质量 ]:
284.08700

[ PSA ]:
172.40000

[ 蒸汽压 ]:
3.13E-15mmHg at 25°C

[ 折射率 ]:
2.059

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ6157200

CHEMICAL NAME :: 7H-v-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-3,6-dihydro-3-beta-D-ribofuranosyl

CAS REGISTRY NUMBER :: 2133-80-4

BEILSTEIN REFERENCE NO. :: 0046037

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H12-N6-O5

MOLECULAR WEIGHT :: 284.27

WISWESSER LINE NOTATION :: T56 BNNN FVM INJ HZ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 7,69,1970