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L-丙氨酸-2-d

L-丙氨酸-2-d用途

L-丙氨酸-2-d1是氘标记的L-丙氨酸-2[1]。

L-丙氨酸-2-d名称

[ CAS 号 ]:
21386-65-2

[ 中文名 ]:
L-丙氨酸-2-d

[ 英文名 ]:
L-Alanine (2-D)

[英文别名 ]:

Alanine-2-d
DL-Alanine-2-d
MFCD00084105
L-alanine-2-d1
L-Alanine-2-d
(2-H)Alanine
L-Methionine-methyl-13C,N-t-Boc derivative
L-alanine-C*-d1

L-丙氨酸-2-d生物活性

[ 描述 ]:

L-丙氨酸-2-d1是氘标记的L-丙氨酸-2[1]。

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

L-丙氨酸-2-d物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
212.9±23.0 °C at 760 mmHg

[ 熔点 ]:
47-50ºC(lit.)

[ 分子式 ]:
C₃H₆DNO₂

[ 分子量 ]:
90.10

[ 闪点 ]:
82.6±22.6 °C

[ 精确质量 ]:
90.053955

[ PSA ]:
63.32000

[ LogP ]:
-0.68

[ 蒸汽压 ]:
0.1±0.9 mmHg at 25°C

[ 折射率 ]:
1.460

L-丙氨酸-2-d安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

L-丙氨酸-2-d合成路线

详细合成路线

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L-丙氨酸-2-d文献

Transformation with TT8 and HB12 RNAi Constructs in Model Forage (Medicago sativa, Alfalfa) Affects Carbohydrate Structure and Metabolic Characteristics in Ruminant Livestock Systems.

J. Agric. Food Chem. 63 , 9590-600, (2015)

Lignin, a phenylpropanoid polymer present in secondary cell walls, has a negative impact on feed digestibility. TT8 and HB12 genes were shown to have low expression levels in low-lignin tissues of alf...

Antimicrobial, Rheological, and Thermal Properties of Plasticized Polylactide Films Incorporated with Essential Oils to Inhibit Staphylococcus aureus and Campylobacter jejuni.

J. Food Sci. 81 , E419-29, (2016)

Polylactide (PLA) is the most mature biobased and biodegradable polymer. Due to its inherent brittleness, the polymer cannot be used as a packaging material without plasticizer. An attempt was made to...

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