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D-丙氨酸

D-丙氨酸用途

D-Alanine 是 GlyR 和PMBA 的弱激动剂,其对 GlyR 的 EC 50 值为 9 mM。

D-丙氨酸名称

[ CAS 号 ]:
338-69-2

[ 中文名 ]:
D-丙氨酸

[ 英文名 ]:
D-alanine

[中文别名 ]:

[英文别名 ]:

(R,S)-Alanine
(±)-Alanine
(R)-2-aminopropanoic acid
D-a-Alanine
Alanine, D-
Propanoic acid, 2-amino-
(±)-2-Aminopropionic acid
2-amino-propanoic acid
D-α-aminopropionic acid
Alanine,D

D-丙氨酸生物活性

[ 描述 ]:

D-Alanine 是 GlyR 和PMBA 的弱激动剂,其对 GlyR 的 EC 50 值为 9 mM。

[ 相关类别 ]:

研究领域 >> 其他

天然产物 >> 其他

[ 靶点 ]

GlyR:9 mM (EC50)

PMBA

Human Endogenous Metabolite

[参考文献]

[1]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27.

[2]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70.

[相关活性小分子]

D-丙氨酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
212.9±23.0 °C at 760 mmHg

[ 熔点 ]:
278-282ºC

[ 分子式 ]:
C₃H₇NO₂

[ 分子量 ]:
89.093

[ 闪点 ]:
82.6±22.6 °C

[ 精确质量 ]:
89.047676

[ PSA ]:
63.32000

[ LogP ]:
-0.68

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.1±0.9 mmHg at 25°C

[ 折射率 ]:
1.460

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶

D-丙氨酸MSDS

D-丙氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922499990

D-丙氨酸合成路线

D-丙氨酸上下游产品

D-丙氨酸上游产品

D-丙氨酸下游产品

D-丙氨酸制备

① 以L天冬氨酸为原料经β脱羧酶酶解后精制而得。

② 由绢丝、明胶、玉米蛋白之类含有L丙氨酸较多的蛋白质水解或酶解后分离而得。

L天冬氨酸固定化酶柱↓酶制备←菌种IAM真空浓缩冷冻结晶

离心分离干燥产品

D-丙氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

D-丙氨酸文献

Evaluation of amino acid ester-based ionic liquids as buffer additives in CE for the separation of 2-arylpropionic acids nonsteroidal anti-inflammatory drugs.

Electrophoresis 35(18) , 2573-8, (2014)

The aim of the present study is the CE performance evaluation for the separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. In particular, the separation of indoprofen, carprofen, k...

A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening.

Biomed Res. Int. 2015 , 419383, (2015)

With the increasing need of effective antibiotics against multi-drug resistant pathogens, lantibiotics are an attractive option of a new class of molecules. They are ribosomally synthetized and posttr...

Knockout of the alanine racemase gene in Aeromonas hydrophila HBNUAh01 results in cell wall damage and enhanced membrane permeability.

FEMS Microbiol. Lett. 362 , fnv089, (2015)

This study focused on the alanine racemase gene (alr-2), which is involved in the synthesis of d-alanine that forms the backbone of the cell wall. A stable alr-2 knockout mutant of Aeromonas hydrophil...

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