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D-谷氨酸

D-谷氨酸用途

D-glutamic acid是L-glutamic acid的对映异构体,广泛用于药物和食品中。

D-谷氨酸名称

[ CAS 号 ]:
6893-26-1

[ 中文名 ]:
D-谷氨酸

[ 英文名 ]:
D(-)-Glutamic acid

[中文别名 ]:

[英文别名 ]:

H-D-Glu-OH
Glutamic acid, D-
MFCD00063112
D(-)-Glutamic acid
glutamic acid D-form
EINECS 230-000-8
δ-Glutamic acid
hydrogen D-glutamate
d-Glu
(R)-(-)-GLUTAMIC ACID

D-谷氨酸生物活性

[ 描述 ]:

D-glutamic acid是L-glutamic acid的对映异构体,广泛用于药物和食品中。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

各种d-氨基酸,如D-丝氨酸,D-天冬氨酸(D-Asp)和D-谷氨酸(D-Glu)广泛存在于包括人类在内的哺乳动物中,现在它们被认为是候选者。新型生理活性物质和/或生物标志物[1]。 D- [Asp/Glu](4mg/mL)抑制IgE与花生的结合(75％),而D-Glu,D-Asp没有抑制作用。 IgE对D- [Asp/Glu]具有特异性,可能具有去除IgE或降低IgE与花生过敏原结合的潜力[2]。

[体内研究]

目前,D-谷氨酸作为神经元传递和激素分泌的调节剂受到关注。它仅在哺乳动物中被D-天冬氨酸氧化酶代谢[1]。腹膜内注射后,L-谷氨酸通过α-酮戊二酸分解代谢,而D-谷氨酸转化为正吡咯烷酮羧酸。 D-和L-谷氨酸的碳2在盲肠中转化为乙酸甲基碳。大鼠肝脏和肾脏都催化D-谷氨酸转化为n-吡咯烷酮羧酸[3]。

[动物实验]

大鼠：给雄性白化病大鼠注射L-或D-谷氨酸-2-C14，DL-谷氨酸-5-C14或D-谷氨酸-5-C14。当动物处于乙醚麻醉下时，进行胃管注射或盲肠注射。杀死大鼠后，分离“尸体”和肝脏谷氨酸，降解并测定放射性。 “胴体”是指除肝脏外的整个动物，包括消化的胃肠道[3]。

[参考文献]

[1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52.

[2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53.

[3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9.

[相关活性小分子]

D-谷氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
333.8±32.0 °C at 760 mmHg

[ 熔点 ]:
200-202ºC

[ 分子式 ]:
C₅H₉NO₄

[ 分子量 ]:
147.129

[ 闪点 ]:
155.7±25.1 °C

[ 精确质量 ]:
147.053162

[ PSA ]:
100.62000

[ LogP ]:
-1.43

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
室温

D-谷氨酸MSDS

详细MSDS(安全技术说明书)

D-谷氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918990090

D-谷氨酸合成路线

详细合成路线

D-谷氨酸上下游产品

D-谷氨酸上游产品

D-谷氨酸下游产品

D-谷氨酸制备

【方法一】
以乙酰-DL-谷氨酸为原料，经酰化酶处理后去L-型，精制、干燥得产品。

D-谷氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

D-谷氨酸文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Low resolution X-ray structure of γ-glutamyltranspeptidase from Bacillus licheniformis: opened active site cleft and a cluster of acid residues potentially involved in the recognition of a metal ion.

Biochim. Biophys. Acta 1844(9) , 1523-9, (2014)

γ-Glutamyltranspeptidases (γ-GTs) cleave the γ-glutamyl amide bond of glutathione and transfer the released γ-glutamyl group to water (hydrolysis) or acceptor amino acids (transpeptidation). These ubi...

γ-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABAA receptors in Drosophila.

J. Neurochem. 130(3) , 408-18, (2014)

Drosophila larvae innately show light avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involve...

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