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L-threonolactone

L-threonolactone用途

L-苏氨酸内酯((3R,4S)-3,4-二羟基氧杂环戊烯-2-酮)是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

L-threonolactone名称

[ CAS 号 ]:
21730-93-8

[ 英文名 ]:
L-threonolactone

[英文别名 ]:

2,3-dihydroxydihydrofuran-1-one
Threonolactone
di-TMS-Threono-1,4-lactone
(3R,4S)-3,4-Dihydroxydihydrofuran-2(3H)-one
L-threonic acid-4-lactone
threonic acid-1,4-lactone
L-treono-1,4-lactone
L-Threonic acid-1,4-lactone
(3R,4S)-3,4-dihydroxyoxolan-2-one
Bis-TMS-Threono-1,4-lactone

L-threonolactone生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

L-threonolactone物理化学性质

[ 密度 ]:
0.99g/cm3

[ 沸点 ]:
277.8ºC at 760mmHg

[ 分子式 ]:
C₄H₆O₄

[ 分子量 ]:
118.09

[ 闪点 ]:
101.3ºC

[ 精确质量 ]:
118.02700

[ PSA ]:
66.76000

[ 蒸汽压 ]:
0.00443mmHg at 25°C

[ 折射率 ]:
1.437

L-threonolactone安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

L-threonolactone上下游产品

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L-threonolactone海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

L-threonolactone文献

A convenient preparation of aldonohydroxamic acids in water and crystal structure of L-erythronohydroxamic acid.

Carbohydr. Res. 335(3) , 195-204, (2001)

Hydroxamic acids derived from aldonic acids, namely aldonohydroxamic acids, have become an increasingly important class of inhibitors of enzymes involved in the metabolism of carbohydrates. We now rep...

Alkaline and smith degradation of oxidized dermatan sulphate-chondroitin sulphate copolymers.

Carbohydr. Res. 36(2) , 349-58, (1974)

Metabolism of l-Threonic Acid in Rumex x acutus L. and Pelargonium crispum (L.) L'Hér.

Plant Physiol. 69(6) , 1365-8, (1982)

l-Threonic acid is a natural constituent in leaves of Pelargonium crispum (L.) L'Hér (lemon geranium) and Rumex x acutus L. (sorrel). In both species, l-[(14)C]threonate is formed after feeding l-[U-(...

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