Photoswitchable PAD inhibitor

Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity. Without photoactivation, it is a weak inhibitor of PAD2 and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro. It does not inhibit histone H3 citrullination in HEK293T cells overexpressing PAD2. However, it can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination.

[ 密度 ]:
1.3±0.1 g/cm3

[ 分子式 ]:
C₂₆H₂₆ClN₇O

[ 分子量 ]:
487.984

[ 精确质量 ]:
487.188751

[ LogP ]:
4.19

[ 折射率 ]:
1.672

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：Photoswitchable PAD Inhibitor (technical grade)

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥9016.0/5mg ￥需询单/500mg ￥2212.0/1mg ￥需询单/1g

联系人：李先生

产品详情：Photoswitchable PAD Inhibitor (technical grade)

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