环黄杨碱 D

环黄杨碱 D用途

Cyclobuxine D 是一种从 Buxus microphylla 中提取的甾体生物碱。Cyclobuxine D 能明显减慢大鼠心率,并对乙酰胆碱和 Ba++ 诱导的兔空肠纵肌收缩具有抑制作用。

环黄杨碱 D名称

[ CAS 号 ]:
2241-90-9

[ 中文名 ]:
环黄杨碱 D

[ 英文名 ]:
Cyclobuxine D

[英文别名 ]:

cyclobuxine
cyclobuxine D

环黄杨碱 D生物活性

[ 描述 ]:

Cyclobuxine D 是一种从 Buxus microphylla 中提取的甾体生物碱。Cyclobuxine D 能明显减慢大鼠心率,并对乙酰胆碱和 Ba++ 诱导的兔空肠纵肌收缩具有抑制作用。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 炎症/免疫

[参考文献]

[1]. . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.

[2]. Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109.

环黄杨碱 D物理化学性质

[ 密度 ]:
1.08g/cm3

[ 沸点 ]:
494.2ºC at 760mmHg

[ 熔点 ]:
236-238ºC

[ 分子式 ]:
C₂₅H₄₂N₂O

[ 分子量 ]:
386.61400

[ 闪点 ]:
53.5ºC

[ 精确质量 ]:
386.33000

[ PSA ]:
44.29000

[ LogP ]:
4.90400

[ 蒸汽压 ]:
7.7E-12mmHg at 25°C

[ 折射率 ]:
1.561

环黄杨碱 D毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ0590020

CHEMICAL NAME :: 9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 14-methyl-3-beta,20-alpha-bis(methylamino)-4- methylene-

CAS REGISTRY NUMBER :: 2241-90-9

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C25-H42-N2-O

MOLECULAR WEIGHT :: 386.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),217,1982