三羰基二氯代钌二聚物

三羰基二氯代钌二聚物用途

Tricarbonyldichlororuthenium(II) dimer 是释放 CO 的药理供体。Tricarbonyldichlororuthenium(II) dimer 释放的 CO 阻止了缺血/再灌注 (I/R) 引起的胃粘膜氧化损伤,改善了胃血流量 (GBF) ,降低了系统水平的 DNA 氧化和炎症反应。

三羰基二氯代钌二聚物名称

[ CAS 号 ]:
22594-69-0

[ 中文名 ]:
三羰基二氯代钌二聚物

[ 英文名 ]:
Tricarbonyldichlororuthenium(II) dimer

[中文别名 ]:

三羰基二氯代钌(II)二聚物

[英文别名 ]:

MFCD00011528
corm-2

三羰基二氯代钌二聚物生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Magierowska K, et, al. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec; 145:198-208.

三羰基二氯代钌二聚物物理化学性质

[ 熔点 ]:
208ºC (dec.)

[ 分子式 ]:
C₆Cl₄O₆Ru₂

[ 分子量 ]:
512.01300

[ 精确质量 ]:
511.65400

[ LogP ]:
1.51000

[ 外观性状 ]:
crystal | off-white

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Insoluble in water

三羰基二氯代钌二聚物MSDS

详细MSDS(安全技术说明书)

三羰基二氯代钌二聚物安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN3466

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

三羰基二氯代钌二聚物制备

三羰基二氯代钌二聚物文献

The CO donor CORM-2 inhibits LPS-induced vascular cell adhesion molecule-1 expression and leukocyte adhesion in human rheumatoid synovial fibroblasts.

Br. J. Pharmacol. 171(12) , 2993-3009, (2014)

Infection with Gram-negative bacteria has been recognized as an initiator of rheumatoid arthritis, which is characterized by chronic inflammation and infiltration of immune cells. Carbon monoxide (CO)...

Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells.

Int. J. Mol. Sci. 15(10) , 17974-99, (2014)

Mesenchymal stem cell (MSC) administration is a promising adjuvant therapy to treat tissue injury. However, MSC survival after administration is often hampered by oxidative stress at the site of injur...

Carbon monoxide (CO) is a novel inhibitor of connexin hemichannels.

J. Biol. Chem. 289(52) , 36150-7, (2014)

Hemichannels (HCs) are hexamers of connexins that can form gap-junction channels at points of cell contacts or "free HCs" at non-contacting regions. HCs are involved in paracrine and autocrine cell si...

更多文献