查杷任酮

查杷任酮用途

Chaparrinone 是一种苦木素类化合物,可以从 Eurycoma Harmandiana 的根中分离出来。 Chaparrinone 对 Plasmodium falciparum 和 P-388 细胞具有抗疟和细胞毒活性 (IC50 分别为 0.037 和 0.34 μg/mL)。

查杷任酮名称

[ CAS 号 ]:
22611-34-3

[ 中文名 ]:
查杷任酮

[ 英文名 ]:
Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)- (9CI)

[英文别名 ]:

Chaparvinon

查杷任酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8.

[2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40.

查杷任酮物理化学性质

[ 密度 ]:
1.45g/cm3

[ 沸点 ]:
626.1ºC at 760mmHg

[ 分子式 ]:
C₂₀H₂₆O₇

[ 分子量 ]:
378.42

[ 闪点 ]:
224.9ºC

[ 精确质量 ]:
378.16800

[ PSA ]:
113.29000

[ LogP ]:
0.16620

[ 蒸汽压 ]:
2.67E-18mmHg at 25°C

[ 折射率 ]:
1.627

查杷任酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7863800

CHEMICAL NAME :: Picras-3-ene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1-beta,11-beta,12-alpha)-

CAS REGISTRY NUMBER :: 22611-34-3

LAST UPDATED :: 199303

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H26-O7

MOLECULAR WEIGHT :: 378.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 26,345,1991