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3-羟基-DL-正缬氨酸

3-羟基-DL-正缬氨酸用途

生化研究，氨基酸发酵中竞争性抑制剂。

3-羟基-DL-正缬氨酸名称

[ CAS 号 ]:
2280-42-4

[ 中文名 ]:
DL-β-羟基去甲缬氨酸

[ 英文名 ]:
dl-3-hydroxynorvaline

[中文别名 ]:

DL-2-氨基-3-羟基戊酸

[英文别名 ]:

2-Amino-3-hydroxy-valeriansaeure
2-amino-3-hydroxypentanoic acid
3-Hydroxynorvaline
2-Amino-3-hydroxymethylpyrazin
DL-3-Hydroxynorvaline
2-amino-3-hydroxy-valeric acid

3-羟基-DL-正缬氨酸生物活性

[ 描述 ]:

DL-3-羟基诺伐碱是缬氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

3-羟基-DL-正缬氨酸物理化学性质

[ 密度 ]:
1.237g/cm3

[ 沸点 ]:
328.4ºC at 760mmHg

[ 熔点 ]:
231.2℃

[ 分子式 ]:
C₅H₁₁NO₃

[ 分子量 ]:
133.14600

[ 闪点 ]:
152.4ºC

[ 精确质量 ]:
133.07400

[ PSA ]:
83.55000

[ 储存条件 ]:
-20 °C，密封，干燥，充气

3-羟基-DL-正缬氨酸安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2922509090

3-羟基-DL-正缬氨酸合成路线

详细合成路线

3-羟基-DL-正缬氨酸上下游产品

3-羟基-DL-正缬氨酸上游产品

3-羟基-DL-正缬氨酸下游产品

3-羟基-DL-正缬氨酸海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3-羟基-DL-正缬氨酸文献

Perturbation of intestinal microvillar enzyme biosynthesis by amino acid analogs. Evidence that dimerization is required for the transport of aminopeptidase N out of the endoplasmic reticulum.

J. Biol. Chem. 265 , 14566-14571, (1990)

The amino acid analogs canavanine, 3-hydroxynorvaline, thialysine, 6-fluorotryptophan, m-fluorotyrosine, and 2-fluorophenylalanine were incorporated into proteins, synthesized in pig intestinal mucosa...

The requirement of phosphorylation on a threonine residue in the acute regulation of steroidogenesis in MA-10 mouse Leydig cells.

J. Steroid Biochem. Mol. Biol. 46(3) , 337-47, (1993)

In the present study we have used several non-phosphorylatable analogs of the amino acids threonine and serine to determine the role of phosphorylation in the acute regulation of steroidogenesis in MA...

Inhibition of steroidogenesis in rat adrenal cortex cells by a threonine analogue.

J. Steroid Biochem. Mol. Biol. 40(1-3) , 421-9, (1991)

We have investigated the ability of amino acid analogues of serine and threonine to inhibit the increase in steroidogenesis elicited by addition of ACTH or cAMP in cells isolated from the rat adrenal ...

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