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4-羟基吲哚

4-羟基吲哚用途

4-Hydroxyindole 是一类羟基吲哚类,其 4 位上的 1H-吲哚被羟基取代。4-Hydroxyindole 是医药产品和工业聚合物合成的重要原料或中间体。

4-羟基吲哚名称

[ CAS 号 ]:
2380-94-1

[ 中文名 ]:
4-羟基吲哚

[ 英文名 ]:
4-Hydroxyindole

[中文别名 ]:

[英文别名 ]:

1H-Indol-4-ol
4-Hydroxylndole
1H-Indol-7-ol
EINECS 219-177-2
indol-4-ol
7-Hydroxyindol
7-HYDROXYLINDOLE
4-hydroxy-indole
INDOL-7-OL
7-HYDROXY-1H-INDOLE

4-羟基吲哚生物活性

[ 描述 ]:

4-Hydroxyindole 是一类羟基吲哚类,其 4 位上的 1H-吲哚被羟基取代。4-Hydroxyindole 是医药产品和工业聚合物合成的重要原料或中间体。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Nenad Manevski, et al. Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos. 2010 Mar;38(3):386-95.

4-羟基吲哚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
343.2±15.0 °C at 760 mmHg

[ 熔点 ]:
97-99 °C(lit.)

[ 分子式 ]:
C₈H₇NO

[ 分子量 ]:
133.147

[ 闪点 ]:
161.4±20.4 °C

[ 精确质量 ]:
133.052765

[ PSA ]:
36.02000

[ LogP ]:
1.41

[ 外观性状 ]:
灰白色水晶般的固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.739

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
slightly soluble

4-羟基吲哚MSDS

4-羟基吲哚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

4-羟基吲哚合成路线

4-羟基吲哚上下游产品

4-羟基吲哚上游产品

4-羟基吲哚下游产品

4-羟基吲哚制备

以间苯二酚为原料，经异构化、催化氢化，再用溴代丙酮酸乙酯环合制得4-氧代四氢古马龙羧酸。将其加入经氨饱和的甲醇溶液中，在高压釜加热反应，生成4-氧代四氢吲哚。最后经脱氢、异构化制得4-羟基吲哚

4-羟基吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-羟基吲哚文献

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 68-76, (2014)

• Optimization of a suitable extraction protocol for alkylindoles and their metabolites from biological fluids. • Detection of alkylindoles and their metabolites by means of the GC/MS method adopted b...

Validation and application of an UPLC-MS/MS method for the quantification of synthetic cannabinoids in urine samples and analysis of seized materials from the Portuguese market.

Forensic Sci. Int. 243 , 117-25, (2014)

An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids a...

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.

Drug Metab. Dispos. 38(3) , 386-95, (2010)

We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the 19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. The glucuronidation o...

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