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1-甲基芘

1-甲基芘用途

1-甲基芘是一种荧光探针,也是啮齿动物的致癌物(λex=346 nm；λem=378 nm)[1]。

1-甲基芘名称

[ CAS 号 ]:
2381-21-7

[ 中文名 ]:
1-甲基芘

[ 英文名 ]:
1-Methylpyrene

[英文别名 ]:

Pyrene,3-methyl
1-methyl-pyren
1-Methylpyrene
4-05-00-02475 (Beilstein Handbook Reference)
L666 B6 2AB PJ G1
3-Methylpyrene
Pyrene, 1-methyl-
MFCD00014329
1-methyl pyrene
Methylpyrene

1-甲基芘生物活性

[ 描述 ]:

1-甲基芘是一种荧光探针,也是啮齿动物的致癌物(λex=346 nm；λem=378 nm)[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Monien BH, et al. Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling. Chem Res Toxicol. 2008 Oct;21(10):2017-25.

1-甲基芘物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
387.4±9.0 °C at 760 mmHg

[ 熔点 ]:
72-74 °C(lit.)

[ 分子式 ]:
C₁₇H₁₂

[ 分子量 ]:
216.277

[ 闪点 ]:
178.9±12.8 °C

[ 精确质量 ]:
216.093903

[ LogP ]:
5.63

[ 外观性状 ]:
固体;White to Amber powder to crystal

[ 蒸汽压 ]:
0.0±0.4 mmHg at 25°C

[ 折射率 ]:
1.816

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
DMSO: soluble

1-甲基芘MSDS

详细MSDS(安全技术说明书)

1-甲基芘毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR2460000

CHEMICAL NAME :: Pyrene, 1-methyl-

CAS REGISTRY NUMBER :: 2381-21-7

BEILSTEIN REFERENCE NO. :: 1868500

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C17-H12

MOLECULAR WEIGHT :: 216.29

WISWESSER LINE NOTATION :: L666 B6 2AB PJ G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg/3D-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 180 umol/L/2H

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,4152,1979

1-甲基芘安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UR2460000

[ 海关编码 ]:
2902909090

1-甲基芘上下游产品

1-甲基芘上游产品

1-甲基芘下游产品

1-甲基芘海关

[ 海关编码 ]: 2902909090

[ 中文概述 ]:
2902909090. 其他芳香烃. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:2.0%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量

[ Summary ]:
2902909090 other aromatic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

1-甲基芘文献

Nitroanilines as quenchers of pyrene fluorescence.

ChemPhysChem 13(18) , 4195-201, (2012)

The quenching of pyrene and 1-methylpyrene fluorescence by nitroanilines (NAs), such as 2-, 3-, and 4-nitroaniline (2-NA, 3-NA, and 4-NA, respectively), 4-methyl-3-nitroaniline (4-M-3-NA), 2-methyl-4-...

Polycyclic aromatic hydrocarbons and the diffuse interstellar bands: a survey.

Astrophys. J. 526 Pt 1 , 265-73, (1999)

We discuss the proposal relating the origin of some of the diffuse interstellar bands (DIBs) to neutral and ionized polycyclic aromatic hydrocarbons (PAHs) present in interstellar clouds. Laboratory s...

1-Sulfooxymethylpyrene is an electrophilic mutagen and ultimate carcinogen of 1-methyl- and 1-hydroxymethylpyrene.

Biochem. Biophys. Res. Commun. 228(1) , 105-9, (1996)

1-Hydroxymethylpyrene and 1-sulfooxymethylpyrene were tested for complete carcinogenic activity by repeated s.c. injection in groups of 12 female Sprague-Dawley rats, respectively. A dose of 0.2 mumol...

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