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蓟苦素

蓟苦素用途

Cnicin 是一种倍半萜内酯。Cnicin 具有抗增殖作用,并诱导原发性骨髓瘤细胞死亡。Cnicin 还具有抗 SARS-CoV-2 活性。Cnicin 抑制 SARS CoV-2 的病毒复制,IC50 为 1.18 μg/mL。

蓟苦素名称

[ CAS 号 ]:
24394-09-0

[ 中文名 ]:
蓟苦素

[ 英文名 ]:
CNICIN

[英文别名 ]:

CYNISIN
cnicine
CENTAURIN

蓟苦素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗感染 >> SARS冠状病毒

[参考文献]

[1]. Jöhrer K, et al. Antimyeloma activity of the sesquiterpene lactone cnicin: impact on Pim-2 kinase as a novel therapeutic target. J Mol Med (Berl). 2012 Jun;90(6):681-93.

[2]. Alhadrami HA, et al. Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics. Antibiotics (Basel). 2021 May 7;10(5):542.

蓟苦素物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
622.3ºC at 760 mmHg

[ 熔点 ]:
142-143ºC

[ 分子式 ]:
C₂₀H₂₆O₇

[ 分子量 ]:
378.42

[ 闪点 ]:
219.1ºC

[ 精确质量 ]:
378.16800

[ PSA ]:
113.29000

[ LogP ]:
0.95430

[ 蒸汽压 ]:
4.31E-18mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
2-8°C

蓟苦素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY4300000

CHEMICAL NAME :: Germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha,8-alpha,15-trihydroxy-, 12,6-lactone, 8-(3,4-dihydroxy-2-methylenebutyrate)

CAS REGISTRY NUMBER :: 24394-09-0

LAST UPDATED :: 199012

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H26-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 452 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 53,247,1987

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 29,179,1976

蓟苦素