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金胺O

金胺O用途

金胺O是一种黄色荧光染料,可用于染色抗酸细菌。金胺O在环境中具有毒性和抗性[1][2]。

金胺O名称

[ CAS 号 ]:
2465-27-2

[ 中文名 ]:
金胺

[ 英文名 ]:
Auramine O

[中文别名 ]:

[英文别名 ]:

Auramine Extra
Auramine O [Dye Content
Basic Yellow 2
MFCD00012484
Auramine Pure
Auramine N
Auramine O
AURAMINE HYDROCHLORIDE
Aizen auramine
EINECS 219-567-2

金胺O生物活性

[ 描述 ]:

金胺O是一种黄色荧光染料,可用于染色抗酸细菌。金胺O在环境中具有毒性和抗性[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kommareddi S, et al. Nontuberculous mycobacterial infections: comparison of the fluorescent auramine-O and Ziehl-Neelsen techniques in tissue diagnosis. Hum Pathol. 1984 Nov;15(11):1085-9.

[2]. Hosseinpour S A, et al. Use of metal composite MOF‐5‐Ag2O‐NPs as an adsorbent for the removal of Auramine O dye under ultrasound energy conditions. Applied Organometallic Chemistry, 2018, 32(2): e4007.

金胺O物理化学性质

[ 密度 ]:
1.01g/cm3

[ 沸点 ]:
406.2ºC at 760mmHg

[ 熔点 ]:
>250 °C (dec.)(lit.)

[ 分子式 ]:
C₁₇H₂₂ClN₃

[ 分子量 ]:
303.830

[ 闪点 ]:
199.4ºC

[ 精确质量 ]:
303.150238

[ PSA ]:
30.33000

[ LogP ]:
4.13650

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
8.31E-07mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥,与氧化剂，食品原料分开存放

[ 水溶解性 ]:
水溶性：实际上不溶；极微溶：乙醇

金胺OMSDS

详细MSDS(安全技术说明书)

金胺O毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY3675000

CHEMICAL NAME :: Aniline, 4,4'-(imidocarbonyl)bis(N,N-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 2465-27-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C17-H21-N3.Cl-H

MOLECULAR WEIGHT :: 303.87

WISWESSER LINE NOTATION :: 1N1&R DYUM&R DN1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/kg/87W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32760 mg/kg/39W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1444 No. of Facilities: 1184 (estimated) No. of Industries: 17 No. of Occupations: 22 No. of Employees: 10114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1444 No. of Facilities: 1191 (estimated) No. of Industries: 27 No. of Occupations: 24 No. of Employees: 19092 (estimated) No. of Female Employees: 4705 (estimated)

金胺O安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H311-H351

[ 警示性声明 ]:
P280-P312

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R22;R24;R40

[ 安全声明 (欧洲) ]:
S36/37-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BY3675000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2925290090

金胺O制备

1.由N,N-二甲基苯胺与甲醛进行缩合，经蒸馏；结晶精制后，用硫磺；尿素与氯化铵进行氨化，而后过滤；干燥即得成品。原料消耗(kg、t)N,N-二甲基苯胺（98%） 110甲醛（37%） 460尿素 700硫磺（99%） 350氯化铵 630对氨基苯磺酸（100%） 8精盐7500

金胺O海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

金胺O文献

Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.

Antimicrob. Agents Chemother. 56(4) , 2074-83, (2012)

Efflux pumps extrude a wide variety of chemically unrelated compounds conferring multidrug resistance and participating in numerous physiological processes. Mycobacterium tuberculosis possesses many e...

Confocal laser scanning microscopy elucidation of the micromorphology of the leaf cuticle and analysis of its chemical composition.

Protoplasma 252 , 1475-86, (2015)

Electron microscopy techniques such as transmission electron microscopy (TEM) and scanning electron microscopy (SEM) have been invaluable tools for the study of the micromorphology of plant cuticles. ...

Efficacy of real-time polymerase chain reaction for rapid diagnosis of endobronchial tuberculosis

Int. J. Infect. Dis. 27 , 13-7, (2014)

• We assess the efficacy of realtime PCR of bronchial biopsies for diagnosis of EBTB • Real-time PCR yields better than AFB staining of bronchial brushing or sputum smear • Bronchoscopic types of EBTB...

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金胺O