<生产厂家价格>

核杀菌素

核杀菌素用途

Nucleocidin 是一种抗生素,抑制标签氨基酸从 S-RNA 转运到蛋白质的过程。

核杀菌素名称

[ CAS 号 ]:
24751-69-7

[ 中文名 ]:
Nucleocidin

[ 英文名 ]:
Nucleocidin

[英文别名 ]:

T-3018
Antibiotic T-3018
4'-Fluor-O5'-sulfamoyl-adenosin
5'-O-Sulfamoyl-4'-fluoroadenosine
4'-Fluor-5'-O-sulfamoyladenosin
nucleocidin
Sulfamic acid 4'-fluoro-5'-adenosyl ester
4'-fluoro-O5'-sulfamoyl-adenosine

核杀菌素生物活性

[ 描述 ]:

Nucleocidin 是一种抗生素,抑制标签氨基酸从 S-RNA 转运到蛋白质的过程。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

天然产物 >> 其他

[ 靶点 ]

Antibacterial[1].

[体外研究]

虽然在低浓度的核苷分子中发生明显的抑制作用,但即使在10-3M也不可能获得完全抑制。在核苷酸的任何抑制之前可检测到明显的滞后,并且该滞后期的长度与浓度成反比。 nucleocidin。当将nucleocidin从网状细胞添加到无细胞系统中时获得了类似的结果。相反,在10-3M嘌呤霉素处获得基本上完全抑制,并且仅在最低浓度下可检测到任何滞后。似乎核杀菌素显示出许多抗生素的典型模式,即它在氨酰基-S-RNA形成后的阶段抑制掺入[1]。

[参考文献]

[1]. Florini JR, et al. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8.

[相关活性小分子]

核杀菌素物理化学性质

[ 密度 ]:
2.23g/cm3

[ 沸点 ]:
747.6ºC at 760mmHg

[ 分子式 ]:
C₁₀H₁₃FN₆O₆S

[ 分子量 ]:
364.31000

[ 闪点 ]:
405.9ºC

[ 精确质量 ]:
364.06000

[ PSA ]:
197.08000

[ 蒸汽压 ]:
1.79E-23mmHg at 25°C

[ 折射率 ]:
1.848

[ 储存条件 ]:
-20°C，干燥，密封

核杀菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7400000

CHEMICAL NAME :: Adenosine, 4'-C-fluoro-, 5'-sulfamate

CAS REGISTRY NUMBER :: 24751-69-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H13-F-N6-O6-S

MOLECULAR WEIGHT :: 364.35

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IZ D- ET5OTJ BF B1OSZW CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,297,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Blood - other changes

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 4,716,1956/1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 50 ug/kg

TOXIC EFFECTS :: Blood - other changes

REFERENCE :: ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 4,716,1956/1957