聚乙二醇
聚乙二醇用途
聚乙二醇名称
[ CAS 号 ]:
25322-68-3
[ 中文名 ]:
聚乙二醇
[ 英文名 ]:
Poly(ethylene glycol)
[中文别名 ]:
[英文别名 ]:
- EINECS 203-473-3
- Polyethylene glycol 10000
- Poly(ethylene oxide),approx. M.W. 900,000
- Polyethylene glycol 1000
- Poly(ethylene glycol),average M.W. 200
- Polyethylene glycol 12000
- Polyethylene glycol (PEG)
- Poly(ethylene glycol)
- Poly(ethylene g
- Macrogol 300,PEG
聚乙二醇生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
[相关活性小分子]
聚乙二醇物理化学性质
[ 密度 ]:
1.125
[ 沸点 ]:
250ºC
[ 熔点 ]:
-65ºC
[ 分子式 ]:
C5H12O2
[ 分子量 ]:
104.15
[ 闪点 ]:
171ºC
[ 外观性状 ]:
透明无色粘性液体
[ 蒸汽密度 ]:
>1 (vs air)
[ 蒸汽压 ]:
<0.01 mm Hg ( 20 °C)
[ 折射率 ]:
1.458-1.461
[ 储存条件 ]:
2-8°C
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
H2O: 50 mg/mL, clear, colorless
聚乙二醇MSDS
聚乙二醇毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TQ4025000
- CHEMICAL NAME :
- Polyethylene glycol #1000
- CAS REGISTRY NUMBER :
- 25322-68-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 15
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1413,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15570 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,451,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 22500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,349,1950 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 416 mg/kg/Y-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors
- REFERENCE :
- BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 15,252,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0788 No. of Facilities: 60 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1675 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80189 No. of Facilities: 34023 (estimated) No. of Industries: 237 No. of Occupations: 159 No. of Employees: 487377 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7669 No. of Facilities: 37662 (estimated) No. of Industries: 225 No. of Occupations: 183 No. of Employees: 1335913 (estimated) No. of Female Employees: 861947 (estimated)
聚乙二醇安全信息
[ 符号 ]:
GHS06, GHS08, GHS09
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H311-H373-H411
[ 警示性声明 ]:
P273-P280-P301 + P312 + P330-P302 + P352 + P312-P391-P501
[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ 危害码 (欧洲) ]:
Xi
[ 风险声明 (欧洲) ]:
R36/38
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
TQ4110000
[ 海关编码 ]:
3404900000
聚乙二醇制备
1.乙二醇在催化剂的存在下与环氧乙烷聚合而成。
2.环氧乙烷在异丙醇铝催化下自聚而成。
3.将120#汽油加入反应釜中,在搅拌下加入异丙醇铝作催化剂 ( 催化剂量为单体总量的1.01-1.03%) 。用氮气置换釜中空气后,加入单体环氧乙烷 ( 溶剂∶环氧乙烷=2∶1,质量比) 。在10~20℃下反应4h 。然后逐渐升温至35~40℃,再反应3h。聚合反应结束。将物料转移至蒸馏釜中,蒸出溶剂,冷却析晶,过滤,得粗产品。真空干燥得成品。反应式如下:
聚乙二醇海关
[ 海关编码 ]: 3404900000
聚乙二醇文献
Adv. Pharmacol. Sci. 2011 , 608912, (2011)
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result i...
PDADMAC flocculation of Chinese hamster ovary cells: enabling a centrifuge-less harvest process for monoclonal antibodies.MAbs 7(2) , 413-28, (2015)
High titer (>10 g/L) monoclonal antibody (mAb) cell culture processes are typically achieved by maintaining high viable cell densities over longer culture durations. A corresponding increase in the so...
Localized experimental bone metastasis drives osteolysis and sensory hypersensitivity at distant non-tumor-bearing sites.Breast Cancer Res. Treat. 153 , 9-20, (2015)
Patients with breast cancer metastasis to bone suffer from inadequate pain relief. Animal models provide increased understanding of cancer-induced bone and sensory alterations. The objective of this s...
相关化工产品/化学物质:
推荐生产厂家/供应商:
公司名:武汉吉鑫益邦生物科技有限公司
区域:武汉市江汉区
价格:
¥需询单/500g
¥需询单/1kg
¥需询单/25kg
¥需询单/200kg
联系人:周美玲
产品详情:聚乙二醇
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥468.9/6000g
¥45.9/500g
¥529.9/6000g
¥54.9/500g
联系人:阿拉丁
产品详情:聚乙二醇
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:聚乙二醇1500
公司名:南通润丰石油化工有限公司
区域:南通市崇川区
价格:
¥需询单/1kg
¥需询单/1ton
联系人:曹经理
产品详情:聚乙二醇
公司名:上海吉至生化科技有限公司
区域:上海市奉贤区
价格:
¥98.0/1kg
¥98.0/1kg
¥98.0/500g
¥98.0/1kg
联系人:刘佳
产品详情:聚乙二醇
查看所有供应商请点击:
聚乙二醇相关知识
2022-05-24 18:36:54
聚乙二醇,别名氧化聚乙烯,是一种高分子聚合物,其化学结构式为HO(CH2CH2O)nH ,n是大于4的整数,因此,聚乙二醇的相对分子量从200-7000不等,日常使用时,为了进行区分,通常会在名称后面加数字,比如聚乙二醇-300就表示分子量为300的聚乙二醇。聚乙二醇水溶性良好,和很多有机物具备良...
相关化合物
【聚乙二醇】化源网提供聚乙二醇CAS号25322-68-3,聚乙二醇MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询聚乙二醇上化源网,专业又轻松。>>电脑版:聚乙二醇
标题:聚乙二醇_MSDS_用途_密度_聚乙二醇CAS号【25322-68-3】_化源网 地址:https://www.chemsrc.com/amp/cas/25322-68-3_766012.html