直接紫N

直接紫N用途

Direct Violet 1 是一种偶氮染料,是一种纺织品染料。Direct Violet 1 还是一种 SARS-CoV-2 spike 蛋白与 ACE2 的蛋白-蛋白相互作用 (PPI) 的抑制剂,IC50 为 1.47-2.63 µM。

直接紫N名称

[ CAS 号 ]:
2586-60-9

[ 中文名 ]:
直接青莲N

[ 英文名 ]:
Direct Violet 1

[中文别名 ]:

[英文别名 ]:

Violet N
Pontamine Violet N
cottonvioletr
directvioletc
diazolvioletn
DIAMINE VIOLET
DirectvioletN
benzovioletn
Erie Violet 3R
Dianil Violet H

直接紫N生物活性

[ 描述 ]:

Direct Violet 1 是一种偶氮染料,是一种纺织品染料。Direct Violet 1 还是一种 SARS-CoV-2 spike 蛋白与 ACE2 的蛋白-蛋白相互作用 (PPI) 的抑制剂,IC50 为 1.47-2.63 µM。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> SARS冠状病毒

[ 靶点 ]

IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding)[1]

[体外研究]

直接紫1抑制SARS-CoV-2-S-RBD与人ACE2结合,抑制SARS-CoV-S1S2与ACE2结合,抑制TNF-R1与TNF结合α IC50值为1.47µM、 2.63美元µM、和2.11µM、分别为[1]。直接紫1抑制SARS-CoV-2假病毒进入hACE2表达的宿主细胞呈浓度依赖性,IC50为35.8µM[1]。

[参考文献]

[1]. Damir Bojadzic, et al. Small-Molecule In Vitro Inhibitors of the Coronavirus Spike-ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2. bioRxiv, 2020 Oct 22.

[2]. Wafaa M Abd El-Rahim, et al. Genotoxicity studies on the removal of a direct textile dye by a fungal strain, in vivo, using micronucleus and RAPD-PCR techniques on male rats. J Appl Toxicol. 2008 May;28(4):484-90.

直接紫N物理化学性质

[ 密度 ]:
1.64g/cm3

[ 分子式 ]:
C₃₂H₂₂N₆Na₂O₈S₂

[ 分子量 ]:
728.66200

[ 精确质量 ]:
728.07400

[ PSA ]:
273.10000

[ LogP ]:
10.19860

[ 外观性状 ]:
固体;Red to Dark blue to Black powder to crystal

[ 折射率 ]:
1.771

[ 储存条件 ]:
室温

直接紫NMSDS

详细MSDS(安全技术说明书)

直接紫N毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK1420000

CHEMICAL NAME :: 2-Naphthalenesulfonic acid, 5,5'-(4,4'-biphenylylenebis(azo))bis(6-amino-4-hydrox y-, disodium salt

CAS REGISTRY NUMBER :: 2586-60-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C32-H22-N6-O8-S2.2Na

MOLECULAR WEIGHT :: 728.70

WISWESSER LINE NOTATION :: L66J CZ HSWO JQ BNUNR DR DNUN- BL66J CZ HSWO JQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1125 gm/kg/71W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - leukemia

REFERENCE :: VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 23(7),72,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 gm/kg/71W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Blood - tumors

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 22(10),22,1978

直接紫N安全信息

[ 危害码 (欧洲) ]:
Xi

[ RTECS号 ]:
QK1420000

直接紫N制备

联苯胺重氮化后与γ酸偶合，经盐析，过滤，干燥而制得。