<生产厂家价格>

1,2-苯并异噻唑啉-3-酮

1,2-苯并异噻唑啉-3-酮用途

Benzisothiazolone 是一种异噻唑啉酮杀菌剂。Benzisothiazolone 对大肠杆菌ATCC 8739和酵母NCYC 1354具有生长抑制活性。Benzisothiazolone 可用于生长抑制模式的研究。

1,2-苯并异噻唑啉-3-酮名称

[ CAS 号 ]:
2634-33-5

[ 中文名 ]:
1,2-苯并异噻唑-3-酮

[ 英文名 ]:
Benzisothiazolone

[中文别名 ]:

[英文别名 ]:

Benzisothiazolone
2,3-dihydro-3-oxo-1,2-benzisothiazole
benzo[d]isothiazol-3-one
Proxan
proxel
Proxel AB
proxil
1,2-Benzothiazol-3-ol
EINECS 220-120-9
Benzisothiazolone (BIT)

1,2-苯并异噻唑啉-3-酮生物活性

[ 描述 ]:

Benzisothiazolone 是一种异噻唑啉酮杀菌剂。Benzisothiazolone 对大肠杆菌ATCC 8739和酵母NCYC 1354具有生长抑制活性。Benzisothiazolone 可用于生长抑制模式的研究。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. CollierPJ, et al. Growth inhibitory and biocidal activity of some isothiazolonebiocides. J Appl Bacteriol. 1990 Oct;69(4):569-77.

1,2-苯并异噻唑啉-3-酮物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
204.5±23.0 °C at 760 mmHg

[ 熔点 ]:
154-158ºC

[ 分子式 ]:
C₇H₅NOS

[ 分子量 ]:
151.19

[ 闪点 ]:
77.5±22.6 °C

[ 精确质量 ]:
151.009186

[ PSA ]:
61.10000

[ LogP ]:
1.78

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.745

[ 储存条件 ]:
通风低温干燥

[ 水溶解性 ]:
Soluble in dichloromethane, dimethyl sulfoxide, methanol.

1,2-苯并异噻唑啉-3-酮MSDS

1,2-苯并异噻唑啉-3-酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4620000

CHEMICAL NAME :: 1,2-Benzisothiazol-3(2H)-one

CAS REGISTRY NUMBER :: 2634-33-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H5-N-O-S

MOLECULAR WEIGHT :: 151.19

WISWESSER LINE NOTATION :: T56 BSMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9375 No. of Facilities: 4586 (estimated) No. of Industries: 57 No. of Occupations: 57 No. of Employees: 92923 (estimated) No. of Female Employees: 15307 (estimated)

1,2-苯并异噻唑啉-3-酮安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H317-H318-H400

[ 警示性声明 ]:
P273-P280-P301 + P312 + P330-P305 + P351 + P338 + P310-P333 + P313-P391

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R38;R41;R43;R50

[ 安全声明 (欧洲) ]:
S24-S26-S37/39-S61

[ 危险品运输编码 ]:
UN 3077

[ WGK德国 ]:
2

[ RTECS号 ]:
DE4620000

[ 包装等级 ]:
III

[ 海关编码 ]:
2934200090

1,2-苯并异噻唑啉-3-酮合成路线

1,2-苯并异噻唑啉-3-酮上下游产品

1,2-苯并异噻唑啉-3-酮上游产品

1,2-苯并异噻唑啉-3-酮下游产品

1,2-苯并异噻唑啉-3-酮制备

1,2-苯并异噻唑啉-3-酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,2-苯并异噻唑啉-3-酮文献

Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.

Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011)

The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. Octhilinon...

Solid-phase synthesis of benzisothiazolones as serine protease inhibitors.

Bioorg. Med. Chem. Lett. 9(5) , 663-6, (1999)

An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been...

A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease.

Anal. Biochem. 293(2) , 239-45, (2001)

Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which cont...

更多文献