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闹羊花毒素III

闹羊花毒素III用途

Rhodojaponin III 是一种二萜类化合物,可从 Rhododendron molle 叶子中获得,具有抗炎活性。

闹羊花毒素III名称

[ CAS 号 ]:
26342-66-5

[ 中文名 ]:
闹羊花素-Ⅲ

[ 英文名 ]:
Rhodojaponin III

[中文别名 ]:

[英文别名 ]:

Rhodoislandin B
Rhodojaponin-III
Rhodojaponin III

闹羊花毒素III生物活性

[ 描述 ]:

Rhodojaponin III 是一种二萜类化合物,可从 Rhododendron molle 叶子中获得,具有抗炎活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Zhou J, et al. Anti-inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle. J Nat Prod. 2018 Jan 26;81(1):151-161.

闹羊花毒素III物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
557.3±50.0 °C at 760 mmHg

[ 熔点 ]:
285-287 °C

[ 分子式 ]:
C₂₀H₃₂O₆

[ 分子量 ]:
368.465

[ 闪点 ]:
290.9±30.1 °C

[ 精确质量 ]:
368.219879

[ PSA ]:
113.68000

[ LogP ]:
1.09

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.632

[ 储存条件 ]:
2-8°C，密封，干燥

闹羊花毒素III毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB9225000

CHEMICAL NAME :: 7,9a-Methano-9aH-cyclopenta(b)heptalene-4,8,11,11a,12 (1H)-pentol, 2,3-epoxydodecahydro-1,1, 4,8-tetramethyl-, (2R,3S,3as,4R,4ar,7R,8R,9as,11R,11aR,12R)-

CAS REGISTRY NUMBER :: 26342-66-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H32-O6

MOLECULAR WEIGHT :: 368.52

WISWESSER LINE NOTATION :: T G3 E5 B765 A 1B Q BX HOTJ AQ DQ EQ F1 F1 KQ K1 PQ P1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 35,303,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 140 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 44,259,1980