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7-胺基去乙酰氧基头胞烷酸

7-胺基去乙酰氧基头胞烷酸用途

6-Aminochrysene (6-Aminochrysene) 是芳香胺类的化学治疗剂,用于脾肿大,骨髓性白血病和乳腺癌。

7-胺基去乙酰氧基头胞烷酸名称

[ CAS 号 ]:
2642-98-0

[ 中文名 ]:
7-胺基去乙酰氧基头胞烷酸

[ 英文名 ]:
6-Aminochrysene

[中文别名 ]:

[英文别名 ]:

Chrysen-6-ylamine
6-Amino-chrysen
Chrysen-6-ylamin
6-AMINOCHRYSENE
Chrysenex
Chrysen-6-amine
6-Amc
Chrysonex
6-chrysenylamine
6-Chrysenamine

7-胺基去乙酰氧基头胞烷酸生物活性

[ 描述 ]:

6-Aminochrysene (6-Aminochrysene) 是芳香胺类的化学治疗剂,用于脾肿大,骨髓性白血病和乳腺癌。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

研究领域 >> 炎症/免疫

[体外研究]

6-氨基噻吩通过大鼠肝微粒体抑制苯胺的羟基化,对硝基苯甲醚的0-去甲基化和氨基比林的N-去甲基化。用6-氨基噻吩预处理大鼠可显着降低体外N-去甲基化,但显着增加羟基化和0-去甲基化[1]。

[体内研究]

6-Aminochrysene是体内几种固体实验肿瘤生长的抑制剂,对人乳腺癌具有抑癌作用[1]。向小鼠长期局部皮肤施用6-氨基噻吩诱导3个月后良性皮肤肿瘤和7个月后皮肤恶性肿瘤的发展。雌性小鼠的反应早于雄性。当6-Aminochrysene腹侧而不是背侧应用时,皮肤肿瘤的诱导更快。皮肤应用后尿排泄量约为口服后的两倍[2]。

[动物实验]

大鼠：雄性CD大鼠在处死前每天一次腹膜内注射25,50和100mg / kg的6-氨基噻吩预处理连续3天，这在最后一次给药后24小时进行。控制仅接收溶剂[1]。

[参考文献]

[1]. Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6(4):201-5.

[2]. Lambelin G, et al. Carcinogenicity of 6-aminochrysene in mice. Eur J Cancer. 1975 May;11(5):327-34.

[相关活性小分子]

7-胺基去乙酰氧基头胞烷酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
501.2±19.0 °C at 760 mmHg

[ 熔点 ]:
209-211 °C(lit.)

[ 分子式 ]:
C₁₈H₁₃N

[ 分子量 ]:
243.303

[ 闪点 ]:
286.9±16.8 °C

[ 精确质量 ]:
243.104797

[ PSA ]:
26.02000

[ LogP ]:
4.63

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.814

[ 储存条件 ]:
2-8°C

7-胺基去乙酰氧基头胞烷酸MSDS

详细MSDS(安全技术说明书)

7-胺基去乙酰氧基头胞烷酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GC0500000

CHEMICAL NAME :: 6-Chrysenamine

CAS REGISTRY NUMBER :: 2642-98-0

BEILSTEIN REFERENCE NO. :: 2114213

LAST UPDATED :: 199612

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C18-H13-N

MOLECULAR WEIGHT :: 243.32

WISWESSER LINE NOTATION :: L E6 B666J MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9504 mg/kg/36D-C

TOXIC EFFECTS :: Cardiac - changes in heart weight Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 gm/kg/39W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 50 mg/L

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 13,531,1984

7-胺基去乙酰氧基头胞烷酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
S45-S36/37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GC0500000

[ 海关编码 ]:
2921499090

7-胺基去乙酰氧基头胞烷酸合成路线

详细合成路线

7-胺基去乙酰氧基头胞烷酸上下游产品

7-胺基去乙酰氧基头胞烷酸上游产品

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7-胺基去乙酰氧基头胞烷酸海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

7-胺基去乙酰氧基头胞烷酸文献

Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium NM6001 and NM6002.

Carcinogenesis 20(6) , 1079-83, (1999)

Human NAT1 and NAT2 genes were subcloned into pACYC184 vector and the plasmids thus obtained were introduced into Salmonella typhimurium O-acetyltransferase-deficient strain NM6000 (TA1538/1, 8-DNP/pS...

Quantitative microspectrofluorimetry study of the "blocking effect" of 6-aminochrysene on benzo[a]pyrene metabolism using single living cells.

Toxicology 29(4) , 345-56, (1984)

By microspectrofluorimetry on single living cells (murine fibroblasts 3T3), we have obtained monoexponential decreases of fluorescence intensity for benzo[a]pyrene (B[a]P) and 6-aminochrysene (6a-chry...

Determination of polycyclic aromatic amines in skin by liquid chromatography with electrochemical detection.

J. Chromatogr. A. 354 , 442-8, (1986)

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