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美西拉宗

美西拉宗用途

Meseclazone 是一种非甾体抗炎药 (NSAID)，具有抗炎，止痛和解热活性。

美西拉宗名称

[ CAS 号 ]:
29053-27-8

[ 中文名 ]:
美西拉宗

[ 英文名 ]:
Meseclazone

[中文别名 ]:

甲塞克那唑

[英文别名 ]:

Meseclazone
NSC297623

美西拉宗生物活性

[ 描述 ]:

Meseclazone 是一种非甾体抗炎药 (NSAID),具有抗炎,止痛和解热活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体内研究]

Meseclazone在口服给药后1小时和4小时抑制胶原诱导的聚集[1]。静脉注射Meseclazone和其他非甾体类抗炎药引起支气管收缩的剂量依赖性抑制,导致下降的效力下降顺序：异丙肾上腺素与吲哚美辛相比,大于阿司匹林的剂量大于阿司匹林,大于萘普芬,大于苯丁酮的布洛芬浓度大于阿司匹林大于二甲尼嗪大于Meseclazone大于5-CSA [2]。

[参考文献]

[1]. Diamantis W, et al. Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation. Thromb Haemost. 1978 Aug 31;40(1):24-36.

[2]. Diamantis W, et al. Antagonism by meseclazone and other nonsteroidal anti-inflammatory drugs of bradykinin-induced bronchospasm. Pharmacology. 1982;24(4):243-7.

[相关活性小分子]

美西拉宗物理化学性质

[ 密度 ]:
1.47g/cm3

[ 沸点 ]:
435.6ºC at 760mmHg

[ 分子式 ]:
C₁₁H₁₀ClNO₃

[ 分子量 ]:
239.65500

[ 闪点 ]:
217.3ºC

[ 精确质量 ]:
239.03500

[ PSA ]:
38.77000

[ LogP ]:
2.16240

[ 蒸汽压 ]:
8.62E-08mmHg at 25°C

[ 折射率 ]:
1.632

[ 储存条件 ]:
库房低温,通风,干燥

美西拉宗毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY3200000

CHEMICAL NAME :: 2H,9H-Isoxazolo(3,2-b)(1,3)benzoxazin-9-one, 3,3a-dihydro-7-chloro-2-methyl-

CAS REGISTRY NUMBER :: 29053-27-8

LAST UPDATED :: 199409

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H10-Cl-N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,147,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,147,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 33,147,1975 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1280 mg/kg/4D-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 52,454,1980