8-溴腺苷

8-溴腺苷用途

8-溴腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。其受欢迎的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。

8-溴腺苷名称

[ CAS 号 ]:
2946-39-6

[ 中文名 ]:
8-溴腺苷

[ 英文名 ]:
8-Bromoadenosine

[中文别名 ]:

[英文别名 ]:

8-Br-A
8-Bromoadenine-9-β-D-ribofuranoside
8-Bromoadenosine
Adenosine, 8-bromo-
8-BROMO-D-ADENOSINE
6-AMINO-8-BROMOPURINE RIBOSIDE
8-bromo-adenosine
MFCD00005733
EINECS 220-959-0

8-溴腺苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

8-溴腺苷物理化学性质

[ 密度 ]:
2.5±0.1 g/cm3

[ 沸点 ]:
717.7±70.0 °C at 760 mmHg

[ 熔点 ]:
210-212 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₁₂BrN₅O₄

[ 分子量 ]:
346.14

[ 闪点 ]:
387.8±35.7 °C

[ 精确质量 ]:
345.007263

[ PSA ]:
139.54000

[ LogP ]:
-0.30

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.941

[ 储存条件 ]:
2-8°C

8-溴腺苷MSDS

8-溴腺苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

8-溴腺苷合成路线

8-溴腺苷文献

PKA signaling drives mammary tumorigenesis through Src.

Oncogene 34(9) , 1160-73, (2015)

Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary ep...

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.

J. Immunol. 194 , 5472-87, (2015)

PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucin...

更多文献

8-溴腺苷

8-溴腺苷用途

8-溴腺苷名称

8-溴腺苷生物活性

8-溴腺苷物理化学性质

8-溴腺苷MSDS

详细MSDS(安全技术说明书)

8-溴腺苷安全信息

8-溴腺苷合成路线

详细合成路线

8-溴腺苷文献

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