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噻唑兰

噻唑兰用途

MTT是一种广泛用于测量细胞增殖的比色剂。 MTT在活细胞中从黄色还原为紫色甲。

噻唑兰名称

[ CAS 号 ]:
298-93-1

[ 中文名 ]:
噻唑兰

[ 英文名 ]:
Thiazolyl Blue

[中文别名 ]:

[英文别名 ]:

ThiazolylBlue(Mtt)
MttA.R.
Methylthiazoletetrazolium bromide
Thiazolyl Blue
MFCD00011964
EINECS 206-069-5
THIAZOLE BLUE
Thiazolyl blue tetrazolium bromide (MTT)
thiazolyl blue tetrazolium bromide
mmttetrazolium

噻唑兰生物活性

[ 描述 ]:

MTT是一种广泛用于测量细胞增殖的比色剂。 MTT在活细胞中从黄色还原为紫色甲。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

生化试剂

研究领域 >> 其他

[体外研究]

MTT与罗丹明B联合使用以测量线粒体膜电位。 MTT-formazan在线粒体中产生,作为罗丹明的荧光猝灭剂,根据膜电位分布在活细胞膜上。在没有mPMS的情况下,MTT的细胞减少很强。当MTT掺入大的单层脂质体中时,它是不透膜的,因此它通过内吞作用被细胞摄取[1]。

[参考文献]

[1]. Berridge MV, et al. Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-52.

[相关活性小分子]

噻唑兰物理化学性质

[ 熔点 ]:
195 °C (dec.)(lit.)

[ 分子式 ]:
C₁₈H₁₆BrN₅S

[ 分子量 ]:
414.322

[ 精确质量 ]:
413.030975

[ PSA ]:
75.72000

[ LogP ]:
0.28830

[ 外观性状 ]:
淡黄色橙色结晶粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Slightly soluble

噻唑兰MSDS

详细MSDS(安全技术说明书)

噻唑兰毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XF8060000

CHEMICAL NAME :: 2H-Tetrazolium, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-, bromide

CAS REGISTRY NUMBER :: 298-93-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C18-H16-N5-S.Br

MOLECULAR WEIGHT :: 414.36

WISWESSER LINE NOTATION :: T5NNKNJ BR& ER& C- BT5N CSJ D1 E1 &E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 5 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,107,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1328 No. of Facilities: 93 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1106 (estimated) No. of Female Employees: 985 (estimated)

噻唑兰安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335-H341

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R46

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XF8060000

[ 海关编码 ]:
29341000

噻唑兰海关

[ 海关编码 ]: 29341000

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噻唑兰