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鞘氨醇激酶抑制剂

鞘氨醇激酶抑制剂用途

SKI II是一种合成的鞘氨醇激酶 (SK) 抑制剂, 抑制SK1和SK2, IC50值分别为78 μM和45 μM。

鞘氨醇激酶抑制剂名称

[ CAS 号 ]:
312636-16-1

[ 中文名 ]:
4-[[4-(4-氯苯基)-2-噻唑基]氨基]苯酚

[ 英文名 ]:
SKI II

[中文别名 ]:

[英文别名 ]:

Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-
4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol
Kinome_2076
Phenol (4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]
SKI II
SphK-I2,Sphingosine Kinase Inhibitor 2
UUL

鞘氨醇激酶抑制剂生物活性

[ 描述 ]:

SKI II是一种合成的鞘氨醇激酶 (SK) 抑制剂, 抑制SK1和SK2, IC50值分别为78 μM和45 μM。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> SPHK

研究领域 >> 癌症

[参考文献]

[1]. Liu H, et al. SphK1 inhibitor SKI II inhibits the proliferation of human hepatoma HepG2 cells via the Wnt5A/β-catenin signaling pathway. Life Sci. 2016 Apr 15;151:23-9.

[2]. Potì F, et al. SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. Atherosclerosis. 2015 May;240(1):212-5.

[3]. Liu Y, et al. SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells. Oncol Lett. 2014 Jul;8(1):367-373.

[相关活性小分子]

鞘氨醇激酶抑制剂物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
507.1±60.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₁ClN₂OS

[ 分子量 ]:
302.779

[ 闪点 ]:
260.5±32.9 °C

[ 精确质量 ]:
302.028076

[ PSA ]:
73.39000

[ LogP ]:
3.91

[ 外观性状 ]:
white solid

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.709

[ 储存条件 ]:
2-8°C，干燥

鞘氨醇激酶抑制剂MSDS

详细MSDS(安全技术说明书)

鞘氨醇激酶抑制剂安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

鞘氨醇激酶抑制剂文献

Sphingolipids are required for efficient triacylglycerol loss in conjugated linoleic Acid treated adipocytes.

PLoS ONE 10(4) , e0119005, (2015)

Conjugated linoleic acid (CLA) reduces adiposity in human and mouse adipocytes. This outcome is achieved through a variety of biological responses including increased energy expenditure and fatty acid...

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.

Nat. Commun. 6 , 6416, (2015)

Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and hu...

Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells.

Arch. Pharm. Res. 37(9) , 1183-92, (2014)

Ginsenoside compound K (CK) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, ...

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