烟酸单核苷酸

烟酸单核苷酸用途

在 NAD+ 的生物合成中,Nicotinic acid mononucleotide (NAMN) 通过烟酸磷酸核糖基转移酶由烟酸 (NA) 形成。Nicotinate mononucleotide 是 nicotinamide mononucleotide/nicotinic acid mononucleotide 腺苷酰转移酶的底物。

烟酸单核苷酸名称

[ CAS 号 ]:
321-02-8

[ 中文名 ]:
β-NicotinicAcidMononucleotide

[ 英文名 ]:
Nicotinic acid mononucleotide

[英文别名 ]:

3-Carboxy-1-methylpyridiniumiodid
Pyridinium,3-carboxy-1-methyl-,iodide
Trigonelline hydriodide
trigonelline hydroiodide
nicotinic acid mononucleotide
Nicotinsaeure-iodmethylat
Nicotinsaeure-mononucleotid
nicotinic acid methiodide
nicotinate adenine mononucleotide
3-Carboxy-1-methyl-pyridinium,Jodid

烟酸单核苷酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. O'Hara JK, et al. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. PLoS One. 2014 Apr 18;9(4):e94061.

[2]. Khan JA, et al. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007 May;11(5):695-705.

烟酸单核苷酸物理化学性质

[ 分子式 ]:
C₁₁H₁₄NO₉P

[ 分子量 ]:
336.21200

[ 精确质量 ]:
336.04800

[ PSA ]:
167.44000

[ 外观性状 ]:
固体

[ 储存条件 ]:
20°C

烟酸单核苷酸MSDS

详细MSDS(安全技术说明书)

烟酸单核苷酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

烟酸单核苷酸上下游产品

烟酸单核苷酸上游产品

烟酸单核苷酸下游产品

烟酸单核苷酸文献

ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.

Mol. Microbiol. 81(4) , 952-67, (2011)

In the homoacetogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into α-ribotides, which are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not fo...

Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.

Biochim. Biophys. Acta 1840(1) , 464-75, (2014)

Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucle...

Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.

Biochimie 94(2) , 300-9, (2012)

Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesi...

更多文献