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杠柳麻甙

杠柳麻甙用途

Periplocymarin 是从 Periploca sepium 和 Periploca graeca 中分离得到的一种强心苷,是一种潜在的抗癌化合物。

杠柳麻甙名称

[ CAS 号 ]:
32476-67-8

[ 中文名 ]:
杠柳次苷

[ 英文名 ]:
Periplocymarin

[中文别名 ]:

杠柳麻甙

[英文别名 ]:

periplocymarin

杠柳麻甙生物活性

[ 描述 ]:

Periplocymarin 是从 Periploca sepium 和 Periploca graeca 中分离得到的一种强心苷,是一种潜在的抗癌化合物。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

杠柳毒苷抑制PC3、U937、HCT-8、Bel-7402、BGC823、A549和A2780细胞系的体外增殖,IC50值为0.02-0.29μM[2]。

[参考文献]

[1]. Martey ON, et al. Periplocymarin is a potential natural compound for drug development: highly permeable with absence of P-glycoprotein efflux and cytochrome P450 inhibitions. Biopharm Drug Dispos. 2014 May;35(4):195-206.

[2]. Redox-responsive PEGylated self-assembled prodrug-nanoparticles formed by single disulfidebond bridge periplocymarin-vitamin E conjugate for liver cancer chemotherapy. Drug Deliv. 2017 Nov;24(1):1170-1178.

杠柳麻甙物理化学性质

[ 密度 ]:
1.27±0.1 g/cm3 (20 ºC 760 Torr)

[ 沸点 ]:
690.9±55.0℃ at 760 mmHg

[ 熔点 ]:
209-211 ºC

[ 分子式 ]:
C₃₀H₄₆O₈

[ 分子量 ]:
534.68100

[ 精确质量 ]:
534.31900

[ PSA ]:
114.68000

[ LogP ]:
3.25430

[ 储存条件 ]:
室温

[ 水溶解性 ]:
Very slightly soluble (0.43 g/L) (25 ºC)

杠柳麻甙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FH4920610

CHEMICAL NAME :: 5-beta-Card-20(22)-enolide, 3-beta-((2,6-dideoxy-3-O-methyl-beta-D-ribo-hexopyran osyl)oxy)- 5,14-dihydroxy-

CAS REGISTRY NUMBER :: 32476-67-8

LAST UPDATED :: 199304

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H46-O8

MOLECULAR WEIGHT :: 534.76

WISWESSER LINE NOTATION :: L E5 B666TJ A1 E1 IQ MQ F- DT5OV EHJ& OO- FT6OTJ B1 CQ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 155 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 74,223,1942