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绿原酸

绿原酸用途

Chlorogenic acid是咖啡和茶中的主要酚类化合物。它具有一些重要的治疗作用,如抗氧化活性,抗菌,保肝,心脏保护,抗炎,解热,神经保护,抗肥胖,抗病毒,抗微生物,抗高血压。

绿原酸名称

[ CAS 号 ]:
327-97-9

[ 中文名 ]:
绿原酸

[ 英文名 ]:
Chlorogenic acid

[中文别名 ]:

[英文别名 ]:

Hlorogenic acid
Chlorogenic Acid Hydrate
Caffeoyl quinic acid
Chlorogenate
3-Caffeoylquinate
5-caffeoylquinic acid
3-O-Caffeoylquinic acid
3-Caffeoylquinic acid
CHLOROGENIC ACID
3-(3,4-Dihydroxycinnamoyl)quinic Acid Hydrate

绿原酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

研究领域 >> 炎症/免疫

天然产物 >> 苯丙酸类

[参考文献]

[1]. Park JJ, et al. Chlorogenic acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1α/AKT pathway. Cell Oncol (Dordr). 2015 Jan 6.

[2]. Park SH, et al. IRAK4 as a Molecular Target in the Amelioration of Innate Immunity-Related Endotoxic Shock and Acute Liver Injury by Chlorogenic Acid. J Immunol. 2015 Feb 1;194(3):1122-30.

[3]. Kang JW, et al. Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats. Biomol Ther (Seoul). 2014 Sep;22(5):420-5.

[相关活性小分子]

绿原酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
665.0±55.0 °C at 760 mmHg

[ 熔点 ]:
210 °C (dec.)(lit.)

[ 分子式 ]:
C₁₆H₁₈O₉

[ 分子量 ]:
354.309

[ 闪点 ]:
245.5±25.0 °C

[ 精确质量 ]:
354.095093

[ PSA ]:
164.75000

[ LogP ]:
-0.36

[ 外观性状 ]:
白色至略淡黄色-米色粉末

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.690

[ 储存条件 ]:
库房低温,通风,干燥

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

绿原酸MSDS

详细MSDS(安全技术说明书)

绿原酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU8480000

CHEMICAL NAME :: Cyclohexanecarboxylic acid, 3-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)- 1,4,5-trihydroxy-, (1S-(1-alpha,3-beta,4-alpha,5-alpha))-

CAS REGISTRY NUMBER :: 327-97-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C16-H18-O9

MOLECULAR WEIGHT :: 354.34

WISWESSER LINE NOTATION :: L6TJ AQ BQ EVQ EQ COV1U1R CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 111,209,1983

绿原酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R68

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GU8480000

绿原酸合成路线

详细合成路线

绿原酸上下游产品

绿原酸上游产品

绿原酸下游产品

绿原酸制备

1. 天然存在于忍冬科植物蒴蓬(Sambucus javanica Reinw.)全草，千屈菜科植物千屈菜(Lythrum salicaria L.)的花等植物中。也可用化学合成方法得到。

2. 烟草：FC，54；FC，53；FC，BU，6。从緑咖啡豆中分离得到。

绿原酸文献

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

Pathway as a pharmacological target for herbal medicines: an investigation from reduning injection.

PLoS ONE 10(4) , e0123109, (2015)

As a rich natural resource for drug discovery, Traditional Chinese Medicine (TCM) plays an important role in complementary and alternative medical systems. TCM shows a daunting complexity of compounds...

Antioxidant properties, phenolic composition and potentiometric sensor array evaluation of commercial and new blueberry (Vaccinium corymbosum) and bog blueberry (Vaccinium uliginosum) genotypes.

Food Chem. 188 , 583-90, (2015)

Antioxidant properties of juices of newly bred and known blueberry (Vaccinium corymbosum) genotypes and wild bog blueberry (Vaccinium uliginosum) were evaluated by ABTS(+) scavenging capacity (RSC), f...

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绿原酸