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3,4-脱氢-DL-脯氨酸

3,4-脱氢-DL-脯氨酸用途

3,4-脱氢-DL-脯氨酸是脯氨酸衍生物[1]。

3,4-脱氢-DL-脯氨酸名称

[ CAS 号 ]:
3395-35-5

[ 中文名 ]:
3,4-脱氢-DL-脯氨酸

[ 英文名 ]:
L-3-Pyrroline-2-carboxylic acid

[中文别名 ]:

[英文别名 ]:

3,4-Dehydro-DL-proline
3,4-dehydro-D,L-proline
H-DL-PRO(3,4-DEHYDRO)-OH
3,4-DIDEHYDRO-DL-PROLINE
L-3-Pyrroline-2-carboxylic acid
rac-(2R*)-3-Pyrroline-2-carboxylic acid
EINECS 222-243-3
R,S-3,4-dehydroproline
2,5-Dihydro-1H-pyrrole-2-carboxylic acid
H-DL-DELTAPRO-OH

3,4-脱氢-DL-脯氨酸生物活性

[ 描述 ]:

3,4-脱氢-DL-脯氨酸是脯氨酸衍生物[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氨基酸和氨基酸衍生物已被商业化用作能量补充剂。它们影响合成代谢激素的分泌、运动期间的燃料供应、压力相关任务期间的精神表现,并防止运动引起的肌肉损伤。它们被认为是有益的能生膳食物质[1]。

[参考文献]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

3,4-脱氢-DL-脯氨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
279.3±40.0 °C at 760 mmHg

[ 熔点 ]:
245ºC (dec.)(lit.)

[ 分子式 ]:
C₅H₇NO₂

[ 分子量 ]:
113.115

[ 闪点 ]:
122.7±27.3 °C

[ 精确质量 ]:
113.047676

[ PSA ]:
49.33000

[ LogP ]:
0.10

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.521

[ 储存条件 ]:
-15°C

3,4-脱氢-DL-脯氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

3,4-脱氢-DL-脯氨酸合成路线

详细合成路线

3,4-脱氢-DL-脯氨酸上下游产品

3,4-脱氢-DL-脯氨酸上游产品

3,4-脱氢-DL-脯氨酸下游产品

3,4-脱氢-DL-脯氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3,4-脱氢-DL-脯氨酸文献

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.

J. Biol. Chem. 279(53) , 55051-9, (2004)

Three human prolyl 4-hydroxylases (P4Hs) regulate the hypoxia-inducible transcription factors (HIFs) by hydroxylating a Leu-Xaa-Xaa-Leu-Ala-Pro motif. We report here that the two leucines in the Leu-G...

Overexpression of decorin by rat arterial smooth muscle cells enhances contraction of type I collagen in vitro.

Arterioscler. Thromb. Vasc. Biol. 24(1) , 67-72, (2004)

Overexpression of decorin reduces neointimal thickening in balloon-injured carotid arteries of rats by decreasing the volume of neointimal extracellular matrix (ECM). We examined the hypothesis that d...

Enhanced and feedback-resistant gamma-glutamyl kinase activity of an Escherichia coli transformant carrying a mutated proB gene of Streptococcus thermophilus.

FEMS Microbiol. Lett. 182(1) , 143-7, (2000)

We used a PCR-based method to generate a single base pair mutation in the proB gene of Streptococcus thermophilus, which replaced an aspartic acid with a glycine residue at position 192 of the first p...

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